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MMP9 — SIRT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MMP9 → SIRT1 (decreases)
  Evidence: SIRT1 knockdown increased the amount of the lower-molecular- weight active form (85–88 kDa) of MMP9, which was shown by zymography (Fig. 1C, center panel).

Text-mined interactions from Literome

Gao et al., Biochem Biophys Res Commun 2008 : Glucose induced MMP9 expression was also inhibited by SIRT1 in response to Resveratrol
Lee et al., Exp Dermatol 2010 : Herein, we demonstrated that Sirt1 , a putative anti ageing enzyme, reduced MMP-9 transcriptional expression in skin
Lee et al., Life Sci 2011 : These results suggest that the activation of SIRT1 in the presence of resveratrol especially inhibits the expression of MMP-9 in HT1080 cells, providing evidence that resveratrol can be a potential candidate for chemoprevention of cancer