Müller et al., Exp Cell Res 2002
(Carcinoma...) :
Activation of beta-catenin signaling induces expression of the new target gene osteopontin during migration
Robertson et al., Exp Cell Res 2010
(Prostatic Neoplasms) :
Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells ... Osteopontin stimulation leads to an overall increase in beta-catenin protein levels with a resultant transfer of beta-catenin to the nucleus ... Through the nuclear import of beta-catenin , OPN increases both the transcription and protein levels of MMP-7 and CD44, which are known TCF/LEF transcription targets