Wei et al., Cancer Res 2000
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Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation
Li et al., Cell Signal 2005
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Taken together, it was implicated that the oxidizing equivalents might flow from HPO to TRX and then to substrate protein by the dimerization of HPO, and its interaction with TRX finally activates the redox-sensitive transcription factor , suggesting a new redox signal pathway conducted by thiol-disulfide transformation in eukaryocytic cytoplasm
Song et al., Stem Cells Dev 2011
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Overexpression of TRX1 and TRX2 increased ERK1/2 phosphorylation, nuclear factor-kappaB activation, and ß-catenin/Tcf promoter activities and inhibited lucine zipper tumor suppressor 2 expression