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HSP90AA1 — TCF12
Text-mined interactions from Literome
Cox et al., Mol Pharmacol 2003
:
We used signaling by aryl hydrocarbon receptor (AhR), an
Hsp90 dependent
transcription factor , as a functional probe to study the effects of Hsp90 inhibitors in yeast strains with deletion mutations of individual Hsp90 and p23 cochaperone genes
Andersen et al., Development 2012
:
In addition, we show that
centrosome position and motility are
regulated by LIM homeodomain
transcription factor activity, which is specifically required for the development of RB peripheral axons
Chen et al., J Biol Chem 2013
(Colorectal Neoplasms...) :
Secreted
Heat Shock Protein 90a (HSP90a) Induces Nuclear Factor-?B mediated
TCF12 Protein Expression to Down-regulate E-cadherin and to Enhance Colorectal Cancer Cell Migration and Invasion ... This suggests that
TCF12 expression is
required for secreted
HSP90a to enhance CRC cell spreading ... Together, these results suggest that the CD91/IKK/NF-?B signaling cascade is involved in secreted
HSP90a induced
TCF12 expression, leading to E-cadherin down-regulation and enhanced CRC cell migration/invasion