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PI3 — ZGLP1

Text-mined interactions from Literome

Buteau et al., Diabetes 2001 : We previously provided evidence that GLP-1 induces pancreatic beta-cell growth nonadditively with glucose in a phosphatidylinositol-3 kinase (PI-3K) dependent manner ... The results are consistent with a model in which GLP-1 induced PI-3K activation results in PKCzeta translocation to the nucleus, which may play a role in the pleiotropic effects ( DNA synthesis, metabolic enzymes, and insulin gene expression ) of the glucoincretin
Buteau et al., Diabetes 2003 (Prostatic Neoplasms) : Both compounds also suppressed GLP-1 induced PI 3-kinase activation ... The results are consistent with a model in which GLP-1 increases PI 3-kinase activity and enhances beta-cell proliferation via transactivation of the EGFR that would require the proteolytic processing of membrane anchored BTC or other EGF-like ligands
Xie et al., Chin Med J (Engl) 2008 (MAP Kinase Signaling System) : The cultured neonatal rats cardiac myocytes were randomly divided into seven groups : the normal control group, the H/R group, the GLP-1 + H/R group, the GLP-1 + H/R + UO126 ( the p42/44 mitogen activated protein kinase ( MAPK ) inhibitor ) group, the GLP-1 + H/R + LY294002 ( phosphatidylinositol 3-kinase (PI3K) inhibitor ) group, the H/R + UO126 group, and the H/R + LY294002 group
Liberman et al., PloS one 2013 : However, the effect of GLP-1 ( 9-36 ) on PI-3 kinase signaling was not associated with increased intracellular levels of cAMP