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EGLN1 — SETD2
Text-mined interactions from Literome
Wolf et al., Antioxid Redox Signal 2005
(Anoxia...) :
ANG II induces HIF-1alpha by a posttranscriptional mechanism suggesting that
SM20 down-regulation
leads to stabilization of
HIF-1
Berchner-Pfannschmidt et al., Biol Chem 2010
(Osteosarcoma) :
HIF-1 degradation is
controlled by
prolyl hydroxylase 2 (PHD2) which needs to be inhibited for HIF-1 accumulation
Wetterau et al., Wound Repair Regen 2011
(Diabetes Mellitus...) :
Prolyl hydroxylase domain 2 (PHD2) has been implicated in several pathways of cell signaling, most notably in its
regulation of
hypoxia-inducible factor (HIF)-1a stability
Fujita et al., J Bone Miner Res 2012
:
Loss and gain of function analyses using lentiviral knockdown of PHDs and overexpression of individual PHDs show that in nucleus pulposus cells only
PHD2 played a limited role in
HIF-1a degradation ; again HIF-2a degradation was unaffected
Ahmad et al., Am J Respir Cell Mol Biol 2012
(Airway Remodeling...) :
Oxygen sensing prolyl-hydroxylase
(PHD)-2 negatively
regulates hypoxia-inducible factor (HIF)1-a and suppresses the hypoxic response
Niecknig et al., Free radical research 2012
:
Herein, modulation of PHD activity appeared to be the key element, because knockdown and inhibition of the
PHD2 prevented reduction of
HIF-1a
Fujita et al., J Biol Chem 2012
(Intervertebral Disc Displacement) :
Expression of prolyl hydroxylases ( PHDs ) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc : distinct
roles of
PHD2 and PHD3 proteins in controlling
HIF-1a activity in hypoxia ... Reporter analysis shows that the hypoxic induction of the
PHD2 promoter is
HIF-1a dependent , whereas PHD3 promoter/enhancer activity is dependent on both HIF-1a and HIF-2a
Mak et al., Proc Natl Acad Sci U S A 2013
:
These data describe a unique mechanism for the regulation of
HIF-1a stability that
involves ERß mediated transcriptional regulation of
PHD2 and they highlight an unexpected role for PHD2 in maintaining epithelial differentiation