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IL7 — TNC
Text-mined interactions from Literome
Maqbool et al., Matrix Biol 2013
:
ECM-regulatory matricellular proteins are synthesized by several myocardial cell types including CF. We investigated the effects of pro-inflammatory cytokines on matricellular protein expression in cultured human CF. cDNA array analysis of matricellular proteins revealed that
interleukin-1a ( IL-1a, 10ng/ml, 6h ) down-regulated connective tissue growth factor ( CTGF/CCN2 ) mRNA by 80 % and
up-regulated tenascin-C (TNC) mRNA levels by 10-fold in human CF, without affecting expression of thrombospondins 1-3, osteonectin or osteopontin
Gao et al., Immunol Lett 1993
:
Addition of IL-7 into the coculture markedly
enhanced DN
thymocyte-TNC interaction and induced the proliferation and differentiation of DN thymocytes, though
IL-7 alone did not induce the differentiation of DN thymocytes ... Furthermore, we demonstrated that
TNC-R3.1 could support the differentiation of CD3+CD4+CD8- or CD3+CD4-CD8+ thymocytes from CD3-CD4-CD8- thymocytes in the
presence of
IL-7 and IL-2