◀ Back to EPHB2

EPHB2 — PLA2G4A

Text-mined interactions from Literome

Wen et al., J Cell Biochem 2000 : This implies that intracellular Ca ( 2+ ) level is the key factor for induction of cPLA(2) activity and thapsigargin elicited ERK activation itself is substantially sufficient for cPLA(2) activation upon intracellular Ca ( 2+ ) increase
Zhu et al., J Immunol 2001 (MAP Kinase Signaling System) : We also find that cPLA(2) activation caused by fMLP occurs subsequent to and is dependent upon ERK1/2 and p38 MAPK activation
Baker et al., Biochim Biophys Acta 2002 : We conclude that the calcium ionophore A23187 and the receptor agonist fMLP both act through common pathways to stimulate PAF synthesis, with p38 MAP kinase regulating acetyltransferase and supplementing ERK activation of cPLA(2)
Xu et al., J Neurochem 2002 (MAP Kinase Signaling System) : However, complete inhibition of phospho-ERK by U0126, an inhibitor of mitogen activated protein kinase kinase ( MEK ), did not completely inhibit PMA stimulated cPLA2 and AA release
Zhu et al., J Leukoc Biol 2002 : IL-5 induced integrin adhesion of human eosinophils caused by ERK1/2 mediated activation of cPLA2
Han et al., J Biol Chem 2003 : We conclude that the effect of group IIa and V PLA2s on H2O2 induced AA release is dependent upon the presence of cPLA2alpha and the activation of PKC and ERK1/2
Su et al., J Biol Chem 2004 (Chlamydia Infections) : The chlamydia induced phosphorylation of cPLA2 was also blocked by a dominant negative ERK2
Cui et al., Free Radic Biol Med 2006 : In primary proximal tubular epithelial cells exposed to hydrogen peroxide ( H2O2 ), both the selective cPLA2 inhibitors and the cPLA2 antisense oligonucleotides significantly attenuated H2O2 induced arachidonic acid liberation and activation of p38 ( SAPK ), ERK1/2 , and Akt1
Slomiany et al., Inflammopharmacology 2006 : The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary mucin synthesis involves ERK dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation
Slomiany et al., J Physiol Pharmacol 2007 : The results of our findings point to H. pylori LPS induced ERK dependent cPLA(2) activation as a critical factor influencing the level of PAF generation, and hence the extent of pathological consequences of H. pylori infection on the synthesis of gastric mucin
Yazlovitskaya et al., Cell Death Differ 2008 : The role of cPLA(2) in the regulation of radiation induced activation of Akt and ERK1/2 and cell viability was confirmed using human umbilical vein endothelial cells transfected with shRNA for cPLA(2)alpha and cultured embryonic fibroblasts from cPLA(2)alpha ( -/- ) mice
Kang et al., Int Arch Allergy Immunol 2008 (Anaphylaxis) : Either p38 or an ERK inhibitor significantly attenuated not only cPLA(2) phosphorylation and activity, but also the late-phase anaphylaxis ... TNF-alpha-induces cPLA(2) activation through the pathway involving p38 MAPK and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis
Linkous et al., Clin Cancer Res 2009 (Carcinoma, Large Cell...) : In cell culture experiments, inhibition of cPLA2 with AACOCF3 prevented radiation induced activation of ERK1/2 and decreased clonogenic survival of irradiated vascular endothelial cells but not the lung tumor cells
Isenovic et al., Cell Biol Int 2009 : Therefore, this investigation used primary cultured rat VSMCs to examine the role of PI3K and ERK1/2 in the INS dependent phosphorylation of cPLA2 and proliferation induced by INS
Bynagari-Settipalli et al., Arterioscler Thromb Vasc Biol 2012 (Disease Models, Animal...) : Thus, PKCs inhibit cPLA(2) activation by inhibiting ERK and Ca ( 2+ ) ( i ) mobilization
Kundu et al., J Lipid Res 2013 : Importantly, DHETs also rescued chemotaxis in cPLA(2)-deficient monocytes and monocytes with blocked Erk1/2 activity, because Erk controls cPLA(2) activation
Slomiany et al., Inflammopharmacology 2013 : Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on MAPK/ERK mediated activation of IKK-ß and cPLA2 : modulatory effect of ghrelin ... We show that ERK activation by the LPS leads to phosphorylation of the inhibitory ?B kinase-ß ( IKK-ß ) and cytosolic phospholipase A2 (cPLA2) , and is reflected in the upsurge in NF-?B nuclear translocation, induction in COX-2 and iNOS expression, and up-regulation in cPLA2 activity
Crawford et al., Mol Biol Cell 1998 : Treatment of cells with the ERK kinase inhibitor PD98059 completely inhibited the attachment dependent ERK2 phosphorylation but did not inhibit cell spreading, cPLA2 phosphorylation, translocation, or AA release