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EPHB2 — SOCS1

Text-mined interactions from Literome

Frantsve et al., Mol Cell Biol 2001 (Cell Transformation, Neoplastic) : TEL-JAK2, in addition to activating Stat5, associates with Shc and Grb2 and induces activation of Erk2 , and expression of Socs-1 inhibits engagement of each of these signaling molecules
Mooney et al., J Biol Chem 2001 (Insulin Resistance) : SOCS-1 and SOCS-6 do not inhibit insulin dependent IR autophosphorylation, but both proteins inhibit insulin dependent activation of ERK1/2 and protein kinase B in vivo and IR-directed phosphorylation of IRS-1 in vitro
Lue et al., Cell Signal 2006 (MAP Kinase Signaling System) : JAB1 overexpression inhibited sustained, but not transient, ERK phosphorylation ... By contrast, JAB1-knock-down by siRNA revealed that minimum JAB1 levels were necessary for transient activation of ERK by MIF
Tortorella et al., J Gerontol A Biol Sci Med Sci 2006 : These results indicate that defective PI3-K/Akt/ERK1/2 activation, likely dependent on elevated SOCS1 and SOCS3 levels, may affect the GM-CSF capacity to delay neutrophil apoptosis in elderly persons