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AGTR1 — TNF

Text-mined interactions from Literome

Knoblach et al., J Neuroimmunol 1999 (Brain Injuries) : TNF alpha levels increased significantly in the injured cortex at 1 and 4, but not at 12, 24 or 72 h after severe lateral fluid-percussion trauma ( 2.6-2.7 atm )
Szuster-Ciesielska et al., Toxicology 2000 : Cadmium ions at 1 and 10 microM concentration, used alone induced a low, but detectable TNF activity in BAECs, and zinc ions at 1, 10 and 100 microM concentration induced both IFN and TNF activity
Cowling et al., J Biol Chem 2002 : These results suggest that low but persistent IKK activity and I kappa B degradation lead to prolonged NF-kappa B nuclear translocation and maximal AT(1) up-regulation in the continued presence of TNF-alpha
Peng et al., Circ Res 2002 (Cardiomyopathies...) : Tumor necrosis factor-alpha induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis ... We sought to determine if TNF-alpha induced AT1 receptor upregulation alters fibroblast responsiveness to Ang II and if this effect differs from direct TNF-alpha effects on fibroblast functions ... In cardiac fibroblasts with TNF-alpha induced AT1 receptor upregulation, Ang II-stimulated [ 3H ] proline incorporation and TIMP-1 protein production was approximately 2-fold greater than in nonpretreated fibroblasts ... Thus, TNF-alpha induced AT1 receptor upregulation enhances Ang II-mediated functions that favor fibrosis
Siragy et al., Endocrinology 2003 (Albuminuria...) : AT(1) receptor blockade with valsartan prevented the increase in TNF-alpha in the diabetic group
Meli et al., J Neuroimmunol 2004 (Disease Models, Animal...) : At 1 mg/kg q6h TNF484 reduced soluble TNF-alpha and the collagen degradation product hydroxyproline in the cerebrospinal fluid
Berthonneche et al., Cardiovasc Drugs Ther 2005 (Myocardial Infarction...) : Since Angiotensin II type 1 (AT1) receptor can be involved in TNF-alpha production, we have investigated whether early short-term treatment with irbesartan, an AT1 receptor blocker, is able to limit TNF-alpha production within the heart and to improve cardiac function and geometry following MI in rats
Yayama et al., Biol Pharm Bull 2006 : These results suggest that the up-regulation of cardiac B2-receptor expression by LPS is mediated through TNF-alpha , which is produced in the myocardium by two different mechanisms in an AT1-receptor dependent and independent manners, implying the role of the cardiac kallikrein-kinin system in the development of cardiac dysfunction during sepsis
LaMarca et al., Hypertension 2008 (Hypertension, Pregnancy-Induced...) : The purpose of this study was to determine the role of placental ischemia and TNF-alpha in stimulating the AT1-AA and the importance of AT1 receptor activation in mediating hypertension during reductions in uterine perfusion pressure ( RUPP ) and chronic TNF-alpha excess in pregnant rats
Maeda et al., Int Immunopharmacol 2009 : Moreover, the production of IFN-gamma and TNF-alpha through CTL stimulation can be inhibited by the selective AT1R inhibitor, Losartan
Zhou et al., Circulation 2010 (Neovascularization, Pathologic...) : Our findings demonstrate that AT(1)-AA mediated tumor necrosis factor-alpha induction, by overcoming its negative regulator, heme oxygenase-1, is a key underlying mechanism responsible for impaired placental angiogenesis by inducing both sEng and soluble fms-like tyrosine kinase-1 secretion from human villous explants
Ulich et al., Am J Pathol 1990 : Endotoxin ( Salmonella typhus lipopolysaccharide ) injected intravenously induces little or no increase in whole-organ TNF mRNA levels at 15 ', 30 ', 1 degree, 2 degrees, or 4 degrees, whereas serum TNF levels are markedly elevated at 1 and 2 hours
Lv et al., Braz J Med Biol Res 2012 : In the PS group, TNF-a increased at 1 , 3, and 5 weeks and IL-1ß increased significantly after 1 and 3 weeks of stress, and then decreased to normal levels by 5 weeks
Chai et al., Acta Biochim Biophys Sin (Shanghai) 2012 (Pre-Eclampsia) : AT1-AA increased TNF secretion and caspase-3 activities ... AT1 receptor blockade completely abrogated AT1-AA induced TNF-a secretion, caspase-3 activation, and cardiomyocyte apoptosis
Gasparotto et al., Sci Total Environ 2013 : However, CFA at 1mg/mL induced an increase of approximately 338 % in intracellular TNF-a , while release of this proinflammatory cytokine was increased by 1.6-fold
Sasamura et al., Hypertension 1997 : We therefore examined the effects of interleukin-1 alpha ( 220 U/mL [ 10 ng/mL ] ), tumor necrosis factor-alpha ( 280 U/mL [ 100 ng/mL ] ), and interferon gamma ( 100 U/mL ) on Ang II type 1 (AT1) receptors expressed in rat vascular smooth muscle cells ... Tumor necrosis factor-alpha and interferon gamma did not cause a significant change in AT1 binding when administered alone but caused a 30 % reduction in binding when administered together ( P < .05 )
Meng et al., Am J Physiol 1998 (Endotoxemia) : Circulating and myocardial TNF-alpha increased at 1 and 2 h, whereas myocardial contractility was depressed at 4 and 6 h. Pretreatment with cycloheximide or dexamethasone abolished the increase in circulating and myocardial TNF-alpha and preserved myocardial contractile function
Chen et al., Biol Reprod 1999 : TNFalpha significantly inhibited hCG/PRL induced StAR and LHR mRNA expression at 1 and 3 h post-TNFalpha