Saito et al., Arthritis Rheum 2001
:
To determine whether TIA-1 differentially regulates the production of tumor necrosis factor a ( TNFalphalpha ) in macrophages and lymphocytes
Mocellin et al., Int J Cancer 2003
(Sarcoma...) :
These findings support the hypothesis that TNF-alpha induced TIA-1 overexpression might sensitize endothelial cells to proapoptotic stimuli present in the tumor microenvironment and enhance NK cell cytotoxic activity against cancer cells
Suzuki et al., Int J Mol Med 2006
(Arthritis, Rheumatoid...) :
While HuR stabilizes TNF-alpha mRNA and enhances TNF-alpha production, TIA-1 acts as a post-transcriptional silencer, and suppresses the production of the TNF-alpha protein