◀ Back to BCL10
BCL10 — CARD11
Pathways - manually collected, often from reviews:
-
KEGG T cell receptor signaling pathway:
Complex of BCL10-CARD11-MALT1
→
IKBKG
(protein-protein, activation)
-
KEGG B cell receptor signaling pathway:
Complex of BCL10-CARD11-MALT1
→
IKBKG
(protein-protein, activation)
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
PDK1 (PDPK1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
MALT1 (MALT1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
BCL10 (BCL10)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
CARD11 (CARD11)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
BCL10 (BCL10)
→
CARD11 (CARD11)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
TAK1 (MAP3K7)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
CARD11 (CARD11)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
CARD11 (CARD11)
→
BCL10 (BCL10)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
→
BCL10 (BCL10)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
→
MALT1 (MALT1)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
GAB2 (GAB2)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, inhibits)
Sun et al., Mol Cell 2004, Parry et al., J Immunol 2006
Evidence: assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
PDK1 (PDPK1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
CARD11 (CARD11)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
BCL10 (BCL10)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
MALT1 (MALT1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
CARD11 (CARD11)
→
BCL10 (BCL10)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TRAF6 (TRAF6)
→
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TRAF6 (TRAF6)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
IKK complex complex (CHUK-IKBKB-IKBKG)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
AKT1 (AKT1)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
TRAF6 (TRAF6)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
→
IKK alpha (CHUK)
(modification, activates)
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TRAF6 (TRAF6)
→
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TRAF6 (TRAF6)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
Reactome Reaction:
BCL10
→
CARD11
(reaction)
Wang et al., Nature 2001, Zhou et al., Nature 2004, Thome et al., Nat Rev Immunol 2004*, Shinohara et al., J Exp Med 2005, Sommer et al., Immunity 2005, Lamothe et al., J Biol Chem 2007, Tanner et al., J Biol Chem 2007*, Thome et al., Trends Immunol 2007*, Shinohara et al., Immunol Rev 2009, Zhang et al., Chin Med Sci J 2010
-
Reactome Reaction:
BCL10
→
CARD11
(indirect_complex)
Zhou et al., Nature 2004, Thome et al., Nat Rev Immunol 2004*, Sommer et al., Immunity 2005, Tanner et al., J Biol Chem 2007*, Thome et al., Trends Immunol 2007*
-
WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection:
PRKCQ
→
Complex of MALT1-CARD11-BCL10
(activation)
-
WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection:
Complex of MALT1-CARD11-BCL10
→
Complex of IKBKG-IKBKB-CHUK
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
CARD11
—
BCL10
Bertin et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
CARD11
—
BCL10
(affinity chromatography technology)
Bertin et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
CARD11
—
BCL10
(coimmunoprecipitation)
Bertin et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
CARD11
—
BCL10
(imaging technique)
Bertin et al., J Biol Chem 2001*
-
IRef Bind_translation Interaction:
CARD11
—
BCL10
(two hybrid)
Bertin et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(direct interaction, two hybrid)
Bertin et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(direct interaction, pull down)
Bertin et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(physical association, affinity chromatography technology)
Bertin et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(physical association, affinity chromatography technology)
Kojo et al., Proc Natl Acad Sci U S A 2009*
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(physical association, affinity chromatography technology)
Welteke et al., EMBO Rep 2009
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(physical association, affinity chromatography technology)
Oruganti et al., Mol Immunol 2011*
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(physical association, affinity chromatography technology)
Langel et al., J Biol Chem 2008*
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(physical association, affinity chromatography technology)
McCully et al., Mol Cell Biol 2008*
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(colocalization, imaging technique)
Sommer et al., Immunity 2005
-
IRef Biogrid Interaction:
CARD11
—
BCL10
(physical association, affinity chromatography technology)
Park et al., Proc Natl Acad Sci U S A 2013*
-
MIPS CORUM CARMA1-BCL10-MALT1 complex:
CARMA1-BCL10-MALT1 complex complex (BCL10-CARD11-MALT1)
Medeiros et al., Science 2007*
-
MIPS CORUM FYB-CARMA1-BCL-10-MALT1 complex:
FYB-CARMA1-BCL-10-MALT1 complex complex (BCL10-CARD11-FYB-MALT1)
Medeiros et al., Science 2007*
-
IRef Corum Interaction:
Complex of MALT1-CARD11-BCL10-FYB
(association, coimmunoprecipitation)
Medeiros et al., Science 2007*
-
IRef Dip Interaction:
Complex of BCL10-MALT1-BCL10-MALT1-CSNK1A1-CSNK1A1-CARD11-CARD11
(anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
-
IRef Dip Interaction:
Complex of CARD11-MALT1-IKBKB-CSNK1A1-BCL10
(anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
-
IRef Dip Interaction:
CARD11
—
BCL10
(physical association, anti bait coimmunoprecipitation)
Kojo et al., Proc Natl Acad Sci U S A 2009*
-
IRef Dip Interaction:
CARD11
—
BCL10
(physical association, anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
-
IRef Hprd Interaction:
CARD11
—
BCL10
(in vivo)
Bertin et al., J Biol Chem 2001*, Gaide et al., FEBS Lett 2001
-
IRef Hprd Interaction:
CARD11
—
BCL10
(in vitro)
Bertin et al., J Biol Chem 2001*, Gaide et al., FEBS Lett 2001
-
IRef Innatedb Interaction:
CARD11
—
BCL10
(unknown, -)
Gaide et al., Nat Immunol 2002*
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti bait coimmunoprecipitation)
Eitelhuber et al., EMBO J 2011*
-
IRef Intact Interaction:
CARD11
—
BCL10
(association, anti bait coimmunoprecipitation)
Welteke et al., EMBO Rep 2009
-
IRef Intact Interaction:
CARD11
—
BCL10
(association, anti bait coimmunoprecipitation)
Eitelhuber et al., EMBO J 2011*
-
IRef Ophid Interaction:
CARD11
—
BCL10
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
CARD11
—
BCL10
(aggregation, confirmational text mining)
Bertin et al., J Biol Chem 2001*
-
IRef Ophid Interaction:
BCL10
—
CARD11
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Yan et al., J Biol Chem 1999
:
Mutational analysis indicates that
CARD mediated
mE10 oligomerization is essential for killing activity
Bertin et al., J Biol Chem 2001
:
When expressed in cells,
CARD11 and CARD14 activate NF-kappaB and
induce the phosphorylation of
BCL10 ... When expressed in cells,
CARD11 and CARD14 activate NF-kappaB and
induce the phosphorylation of
BCL10
Gaide et al., FEBS Lett 2001
(Lymphoma) :
Carma1 , a CARD containing binding partner of Bcl10,
induces Bcl10 phosphorylation and NF-kappaB activation ...
Carma1 binds Bcl10 via its CARD motif and
induces translocation of
Bcl10 from the cytoplasm into perinuclear structures ... Moreover, expression of
Carma1 induces phosphorylation of
Bcl10 and activation of the transcription factor NF-kappaB
Lin et al., Semin Immunol 2004
(Lymphoma, B-Cell, Marginal Zone) :
In this review, we will discuss the mechanism by which proximal signaling components connect antigen receptor signaling to CARMA1, and how
CARMA1 regulates
Bcl10 and MALT1, leading to activation of NF-kappaB
Rivera et al., Trends Immunol 2006
:
The
CARMA1-Bcl10-Malt1 adaptor complex
regulates NFkappaB activation by antigen receptors in lymphocytes
Bidère et al., Curr Biol 2006
:
Protein kinase Ctheta ( PKCtheta ),
CARMA1 , and BCL10 are also required for TCR induced caspase-8 relocation, but only PKCtheta and
BCL10 control caspase-8 activation ... Our results suggest that PKCtheta independently controls
CARMA1 phosphorylation and
BCL10 dependent caspase-8
activation and unveil an essential role for TRAF6 as a critical adaptor linking these two convergent signaling events
Ishiguro et al., Mol Immunol 2007
:
Carma1-Bcl10 interaction and the signaling pathway are
controlled by
Carma1 phosphorylation, which are induced by PKCtheta and Ca ( 2+ ) /calmodulin dependent protein kinase II ( CaMKII )
Hara et al., Nat Immunol 2007
(Listeriosis) :
The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Shinohara et al., J Exp Med 2007
:
IkappaB kinase beta induced phosphorylation of
CARMA1 contributes to
CARMA1 Bcl10 MALT1 complex formation in B cells
Langel et al., J Biol Chem 2008
:
We now provide evidence that the death domain of MALT1 and the
CARD of Bcl10 also
contribute to
Bcl10-MALT1 interactions
Edin et al., Mol Immunol 2010
:
Binding of CaM to
Bcl10 is shown to
inhibit the ability of Bcl10 to interact with
Carma1 , an interaction that is required for signaling from the TCR to NF-kappaB