Gene interactions and pathways from curated databases and text-mining

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BCL10 — CARD11

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Yan et al., J Biol Chem 1999 : Mutational analysis indicates that CARD mediated mE10 oligomerization is essential for killing activity
Bertin et al., J Biol Chem 2001 : When expressed in cells, CARD11 and CARD14 activate NF-kappaB and induce the phosphorylation of BCL10 ... When expressed in cells, CARD11 and CARD14 activate NF-kappaB and induce the phosphorylation of BCL10
Gaide et al., FEBS Lett 2001 (Lymphoma) : Carma1 , a CARD containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation ... Carma1 binds Bcl10 via its CARD motif and induces translocation of Bcl10 from the cytoplasm into perinuclear structures ... Moreover, expression of Carma1 induces phosphorylation of Bcl10 and activation of the transcription factor NF-kappaB
Lin et al., Semin Immunol 2004 (Lymphoma, B-Cell, Marginal Zone) : In this review, we will discuss the mechanism by which proximal signaling components connect antigen receptor signaling to CARMA1, and how CARMA1 regulates Bcl10 and MALT1, leading to activation of NF-kappaB
Rivera et al., Trends Immunol 2006 : The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes
Bidère et al., Curr Biol 2006 : Protein kinase Ctheta ( PKCtheta ), CARMA1 , and BCL10 are also required for TCR induced caspase-8 relocation, but only PKCtheta and BCL10 control caspase-8 activation ... Our results suggest that PKCtheta independently controls CARMA1 phosphorylation and BCL10 dependent caspase-8 activation and unveil an essential role for TRAF6 as a critical adaptor linking these two convergent signaling events
Ishiguro et al., Mol Immunol 2007 : Carma1-Bcl10 interaction and the signaling pathway are controlled by Carma1 phosphorylation, which are induced by PKCtheta and Ca ( 2+ ) /calmodulin dependent protein kinase II ( CaMKII )
Hara et al., Nat Immunol 2007 (Listeriosis) : The CARMA1-Bcl-10-MALT1 complex is critical for the activation of transcription factor NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Shinohara et al., J Exp Med 2007 : IkappaB kinase beta induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
Langel et al., J Biol Chem 2008 : We now provide evidence that the death domain of MALT1 and the CARD of Bcl10 also contribute to Bcl10-MALT1 interactions
Edin et al., Mol Immunol 2010 : Binding of CaM to Bcl10 is shown to inhibit the ability of Bcl10 to interact with Carma1 , an interaction that is required for signaling from the TCR to NF-kappaB