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AKT1 — CROT

Text-mined interactions from Literome

Kane et al., Mol Cell Biol 2002 : Akt appears to function upstream of Cot, as Akt can enhance Cot induction of NF-kappa B-dependent transcription, and dominant negative Cot blocks the activation of this element by Akt
López-Peláez et al., Eur J Immunol 2011 : Here, we show that Cot/tpl2 , a MAP3K responsible for the activation of the MKK1-Erk1/2, controls P-Ser473 Akt and P-Thr389 p70 S6k phosphorylation in LPS stimulated macrophages ... Furthermore, in zymosan- and polyI : C-stimulated macrophages, Cot/tpl2 mediates P-Ser473 Akt phosphorylation, increases I?Ba levels and decreases NOS2 expression