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GRIP1 — PRKAR1A

Text-mined interactions from Literome

Hoang et al., J Biol Chem 2004 : Here, we show that GRIP1 is regulated by cAMP dependent protein kinase (PKA) that induces its degradation through the ubiquitin-proteasome pathway ... The proteasome inhibitors MG132 and lactacystin abolished the PKA mediated degradation of GRIP1 ... Using ts20 cells, a temperature-sensitive cell line that contains a thermolabile ubiquitin activating E1 enzyme, it was confirmed that PKA mediated degradation of GRIP1 is dependent upon the ubiquitin-proteasome pathway ... Finally, we show that PKA regulates the intracellular distribution pattern of green fluorescent protein-GRIP1 and stimulates recruitment of GRIP1 to subnuclear foci that are colocalized with the proteasome
Hoang et al., Endocrinology 2013 : Here we show that the cAMP response element binding protein ( CREB ) downregulates GRIP1 and is necessary for the PKA stimulated degradation of GRIP1 , which leads to changes in the expression of a subset of genes regulated by estrogen receptor-a in MCF-7 breast cancer cells ... We propose that CREB mediates the PKA stimulated degradation of GRIP1 through protein-protein interaction and stimulation of proteasomal degradation of ubiquitinated GRIP1