Gene interactions and pathways from curated databases and text-mining

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PARP12 — SIRT1

Text-mined interactions from Literome

Bai et al., Cell Metab 2011 : Also, the pharmacologic inhibition of PARP in vitro and in vivo increased NAD ( + ) content and SIRT1 activity and enhanced oxidative metabolism
Massudi et al., PloS one 2012 : Age associated increases in oxidative nuclear damage have been associated with PARP mediated NAD ( + ) depletion and loss of SIRT1 activity in rodents