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NFKB1 — PRDX2

Text-mined interactions from Literome

Yu et al., J Am Soc Nephrol 2002 : TSA inhibited induction of endogenous NO production and iNOS as well as NF-kappa B element promoter activity in response to interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) in both cell types without altering NF-kappa B DNA binding activity
Rahman et al., Mol Cell Biochem 2002 (Inflammation) : H2O2, and TNF-a, and TSA all increased NF-kappaB and AP-1 DNA binding to their consensus sites assessed by the electrophoretic mobility shift assay
Yao et al., Pharmacol Res 2006 (Carcinoma...) : Coincident with this observation, TSA induced a concentration dependent reduction of constitutive and tumour necrosis factor (TNF)-alpha induced NF-kappaB activation in Tca8113 cells ... Overall, our results indicate inhibition of NF-kappaB activation contributes , at least partially, to the antitumour activity of TSA in human tongue carcinoma cells
Chang et al., Mol Immunol 2007 : TSA1 could also inhibit TNF induced cytotoxicity on L929 cells and TNF mediated NF-kappaB activation on HEK-293T cells
Wang et al., J Biol Chem 2007 (Thrombosis) : A chromatin immunoprecipitation assay and a promoter-luciferase reporter system confirm that TSA inhibits TF-kappaB but not NF-kappaB activation
Domingo-Domènech et al., Breast Cancer Res Treat 2008 (Breast Neoplasms) : We observed that the HDACi suberoylanilide hydroxamic acid ( SAHA ) or trichostatin A (TSA) induced cell death but also enhanced NF-kappaB-activity
Chabane et al., Osteoarthritis Cartilage 2008 : In the present study, we determined the effect of trichostatin A (TSA) and butyric acid ( BA ), two histone deacetylase (HDAC) inhibitors, on NO and PGE ( 2 ) synthesis, inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 expression, and nuclear factor (NF)-kappaB DNA binding activity, in interleukin-1beta (IL-1) stimulated human OA chondrocytes, and on IL-1 induced proteoglycan degradation in cartilage explants
Chavey et al., Mol Pharmacol 2008 (Breast Neoplasms) : These observations are corroborated by an up-regulation of NF-kappaB activity in MCF-7 cells in the presence of TSA
Dong et al., Phytother Res 2009 (Brain Ischemia...) : In vitro, the translocation of NF-kappaB was inhibited by TSA and the survival rate of astrocytes was markedly increased and the NO production was decreased
Wu et al., Gynecol Obstet Invest 2010 (Endometriosis) : To determine whether nuclear factor-kappaB (NF-kappaB) is constitutively and tumor necrosis factor (TNF)-dependently activated in endometriotic cells, whether trichostatin A (TSA) can suppress NF-kappaB activation and suppress TRAF2/6 and TAK1, and whether TSA and caffeic acid phenyl ester can suppress constitutive and H ( 2 ) O ( 2 ) -stimulated proliferation of endometriotic cells ... Electrophoretic mobility shift analysis was used to determine NF-kappaB activation and possible suppression by TSA ... TNFalpha stimulation activated NF-kappaB through induction of IkappaB phosphorylation, but the activation can be suppressed by TSA
Wang et al., FEBS Lett 2010 : TSA-treatment inhibited nuclear translocation of NF-kappaB following IgE mediated, but not LPS induced activation in MCs