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PRKAG2 — TBC1D4

Text-mined interactions from Literome

Treebak et al., Diabetes 2006 : AMPK mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits
Kramer et al., Diabetes 2006 : While Akt and AMPK alpha2 activities are essential for AS160 phosphorylation by insulin and AICAR, respectively, neither kinase is indispensable for the entire effects of contraction on AS160 phosphorylation
Chen et al., Biochem J 2008 : Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators
Funai et al., Diabetes 2009 : To evaluate the roles of AMPK and Akt on insulin- or contraction stimulated PAS-AS160 , PAS-TBC1D1, and glucose transport, rat epitrochlearis was incubated with and without compound C ( inhibitor of AMPK ) or Wortmannin ( inhibitor of phosphatidylinositol [ PI] 3-kinase, which is upstream of Akt ) before and during insulin stimulation or contraction
Pehmøller et al., Am J Physiol Endocrinol Metab 2009 : AMPK activation by AICAR induced similar Ser ( 237 ) and Thr ( 596 ) phosphorylation of, and 14-3-3 binding to, TBC1D1 as muscle contraction
Gaidhu et al., Mol Endocrinol 2010 : However, AMPK activation suppressed the phosphorylation of AS160/TBC1D4 and its interaction with the 14-3-3 signal transduction-regulatory protein, which was accompanied by significant reductions in plasma membrane glucose transporter 4 content and glucose uptake under basal and insulin stimulated conditions
Kusudo et al., Genes Cells 2011 (Obesity) : These results suggest that FABP3 stimulates glucose uptake by facilitating AMPK dependent AS160 phosphorylation in skeletal muscle