Dudek et al., J Biol Chem 2010
:
Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes ... We thus provide evidence that SOX9 positively regulates COL2A1 in human articular chondrocytes via a previously unreported miR-675 dependent mechanism
Abouheif et al., Rheumatology (Oxford) 2010
(Arthritis, Experimental) :
Silencing of miR-34a significantly prevented IL-1ß induced down-regulation of Col2a1 , as well as IL-1ß induced up-regulation of iNOS
Martinez-Sanchez et al., J Biol Chem 2012
(Campomelic Dysplasia) :
Specifically, increased miR-145 levels cause greatly reduced expression of critical cartilage extracellular matrix genes ( COL2A1 and aggrecan ) and tissue-specific microRNAs ( miR-675 and miR-140 ) and increased levels of the hypertrophic markers RUNX2 and MMP13, characteristic of changes occurring in osteoarthritis