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IRF6 — POMC

Text-mined interactions from Literome

Grinevich et al., J Neuroendocrinol 2001 : Repeated LPS ( R-LPS ) decreased body weight and increased adrenal weight and pituitary pro-opiomelanocortin mRNA levels
Iwasaki et al., Endocr J 2008 : In this study, we examined the effects of LPS on ACTH secretion and the transcription of the POMC gene in the AtT20 mouse pituitary corticotroph cell line ... Overall, our data show the expression of TLRs in the pituitary corticotroph cells, and suggest the direct stimulatory effect of LPS on POMC gene expression via TLR ( probably TLR4 ), although the intracellular signaling pathways in the corticotroph may be different from those in immune cells
Jang et al., J Biol Chem 2010 (Anorexia) : In vitro, NF-kappaB activation directly stimulated the transcriptional activity of pro-opiomelanocortin (POMC) , a precursor of anorexigenic melanocortin, and mediated the stimulatory effects of LPS , Tat, and pro-inflammatory cytokines on POMC transcription, implying the involvement of NF-kappaB in controlling feeding behavior