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INS — SOAT1
Text-mined interactions from Literome
Cottet et al., J Biol Chem 2001
(Diabetes Mellitus, Type 1) :
SOCS-1 protein prevents Janus
Kinase/STAT dependent inhibition of beta cell
insulin gene transcription and secretion in response to interferon-gamma
Carvalheira et al., Biol Chem 2003
:
Interaction between leptin and
insulin signaling pathways differentially
affects JAK-STAT and PI 3-kinase mediated signaling in rat liver
Gottardello Zecchin et al., Vascul Pharmacol 2005
(Insulin Resistance...) :
Moreover, it is shown that, in obese animals,
JAK2/STAT and MAP kinase pathways are hyper activated in
response to
insulin , which occurs in association with a reduced activation of PI 3-kinase/Akt pathway in aorta
Kim et al., Mol Cell Endocrinol 2007
:
The findings on beta-cell protective effects of genistein were essentially the same as for the RIN cell data, namely genistein prevented cytokine induced NO production, iNOS expression, ERK-1/2 activation,
JAK/STAT activation , and impairment of glucose stimulated
insulin secretion
Jeong et al., Toxicol In Vitro 2011
:
Sauchinone prevented cytokine induced NO production, iNOS expression,
JAK/STAT activation , and NF-?B activation and inhibition of glucose stimulated
insulin secretion ( GSIS )