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INS — UTS2

Text-mined interactions from Literome

Silvestre et al., Eur J Endocrinol 2004 : Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas ... Previous work from our laboratory has demonstrated that frog urotensin-II (UII) , at a high concentration, inhibits glucose induced insulin release in the rat pancreas ... We have investigated the effect of rat UII and two structural analogs on insulin secretion and searched for the presence of UII-immunoreactivity in rat pancreatic extracts ... UII ( 1 nmol/l ) also inhibited the insulin responses induced by carbachol, glucagon-like peptide-1, and a calcium channel agonist ( BAY K 8644 ) ... In contrast, [ Ala ( 8 ) ] UII ( 4-11 ), a UII analog devoid of contractile activity on rat aortic rings, did not affect glucose induced insulin secretion
Silvestre et al., Regul Pept 2009 : We have investigated the effect of urotensin II (UII) on insulin secretion at normal and high glucose concentrations as well as induced by secretagogues acting on the B cell via different mechanisms ... UII , at 1 nM, blocked the insulin response to an increase in perfusate glucose concentration from 5.5 to 9 mM while failed to significantly modify insulin secretion at higher glucose levels ( from 9 to 13 mM ) ... UII inhibited exendin-4 induced insulin secretion, an effect not observed in pertussis toxin treated rats ... 2 ) The inhibitory effect of UII on both glucose and tolbutamide induced insulin release, suggests the implication of ATP dependent K ( + ) channels
Liu et al., Sheng Li Xue Bao 2010 : [ Urotensin II inhibits glucokinase expression and glucose induced insulin secretion ] ... The purpose of the present study is to investigate the effects of urotensin II (UII) on insulin secretion in islet beta cells and the underlying mechanism ... Glucose tolerance test was performed in Wistar rats to evaluate the effect of UII on the levels of plasma glucose and insulin ... Static incubation experiment was employed to investigate the effect of UII on glucose induced insulin secretion ( GIIS ) in betaTC-6 cells ... The inhibitory effect of UII on insulin secretion is rather associated with a suppression of GCK expression than a regulation on PDX-1 expression
Sáez et al., PloS one 2011 (Insulin Resistance) : Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance ( fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA )