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CCK — NGF
Text-mined interactions from Literome
Tirassa et al., Proc Natl Acad Sci U S A 1999
:
In this study, we demonstrate that
cholecystokinin-8 (CCK-8) induces an increase in both
nerve growth factor (NGF) protein and NGF mRNA in mouse cortex and hippocampus when i.p. injected at physiological doses
Manni et al., Br J Pharmacol 2000
(Peripheral Nervous System Diseases) :
Cholecystokinin-8 enhances
nerve growth factor synthesis and promotes recovery of capsaicin induced sensory deficit
Manni et al., Rheumatology (Oxford) 2002
(Arthritis, Experimental...) :
Role of
cholecystokinin-8 in
nerve growth factor and nerve growth factor mRNA expression in carrageenan induced joint inflammation in adult rats
Manni et al., Clin Exp Rheumatol 2003
(Inflammation...) :
Both interleukin-1-beta (IL-1 beta) and TNF-alpha, but not
CCK-8 promote
NGF synthesis and release from OA cells
Xanthos et al., Neuropharmacology 2009
(Central Nervous System Diseases...) :
We suggest that in intrathecally LPS treated rats, spinal
CCK release is altered resulting in enhanced morphine analgesia, and that this mechanism may be
regulated to an important extent by
NGF
Tirassa et al., Br J Pharmacol 1998
:
4. The effects of
CCK-8 were dose- and time dependent and the injection of 8 nmol kg ( -1 )
resulted in a 3 fold increase of
NGF levels in the hypothalamus and pituitary, and about a 60 % increase in the hippocampus ... Pretreatment with a selective CCK(A) receptor antagonist blocked the
CCK induced
NGF increase in the hypothalamus and pituitary ... Pretreatment with atropine suppressed the
CCK induced effects on
NGF levels in all the brain regions examined