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CDH15 — CTNNB1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
CDH15
→
CTNNB1
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kurth et al., Dev Dyn 1999
:
Overexpression of myc tagged maternal
cadherin leads to a proportionate increase of the level of
beta-catenin ... Expression of
cadherin is
essential for the stable presence of
beta-catenin , as depletion from maternal cadherin mRNA leads to a complete loss of beta-catenin from the blastomeres
Hugh et al., Int J Cancer 1999
(Colonic Neoplasms...) :
beta-catenin plays a fundamental role in the regulation of the
E-cadherin-catenin cell adhesion complex
Gradl et al., Mol Cell Biol 1999
:
beta-Catenin stabilizes the
cadherin cell adhesion complex but, as a component of the Wnt/Wg signaling pathway, also controls gene expression by forming a heterodimer with a transcription factor of the LEF-TCF family
Stewart et al., J Biol Chem 2000
:
Differential regulation of endogenous
cadherin expression in Madin-Darby canine kidney cells by cell-cell adhesion and
activation of
beta -catenin signaling ... To investigate a
role of
beta-catenin in regulation of
cadherin expression in MDCK cells, we examined the effects of expressing signaling-active beta-catenin mutants ( DeltaGSK, DeltaN90, and DeltaN131 )
Imai et al., Development 2000
:
( 3 ) Downregulation of (
beta)-catenin induced by the overexpression of
cadherin resulted in the suppression of endoderm cell differentiation
Goichberg et al., J Cell Sci 2001
:
These results suggest that increased
cadherin mediated adhesion and translocation of
beta-catenin to adherens junctions are involved in activating the early steps of myogenic differentiation
Demunter et al., Mod Pathol 2002
(Disease Progression...) :
beta-Catenin plays a fundamental role in the regulation of the
E-cadherin-catenin cell adhesion complex
Ionescu et al., Microcirculation 2003
:
In the absence of PMNs, the cross linking of
VE-cadherin , but not platelet endothelial cell adhesion molecule-1 or intercellular adhesion molecule-1,
increased the cytoplasmic accumulation of
beta-catenin
Ohira et al., Proc Natl Acad Sci U S A 2003
(Lung Neoplasms) :
Drosophila
DE-cadherin is
regulated by
Wnt/beta-catenin signaling, although this has not been demonstrated in mammalian cells
Gottardi et al., J Cell Biol 2004
:
Beta-catenin plays essential roles in both cell-cell adhesion and Wnt signal transduction, but what precisely
controls beta-catenin targeting to
cadherin adhesive complexes, or T-cell factor ( TCF ) -transcriptional complexes is less well understood
Pacquelet et al., J Cell Biol 2005
:
We found that ( 1 ) although linking DE-cadherin to alpha-catenin is essential, regulation of the link is not required in any of these types of adhesion ; ( 2 )
beta-catenin is
required only to link
DE-cadherin to alpha-catenin ; and ( 3 ) the cytoplasmic domain of DE-cadherin has an additional specific function for the invasive migration of border cells, which is conserved to other cadherins
Fukunaga et al., Cell Struct Funct 2005
:
Loss of both
beta-catenin and plakoglobin expression, however, severely
affected the strong cell adhesion activity of
cadherin
Okuda et al., Proc Natl Acad Sci U S A 2007
:
The normal glutamatergic synaptic response is maintained by postsynaptic
beta-catenin in a
cadherin dependent manner and requires the C-terminal PDZ binding motif of beta-catenin but not the link to the actin cytoskeleton
Genelhu et al., Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2007
(Adenoma, Pleomorphic...) :
Beta-catenin plays a central role in
cadherin/catenin cell-cell adhesion complex and is involved in cell signaling pathway
McCusker et al., Mol Biol Cell 2009
:
Additionally, cleavage of
cadherin-11 does not
affect binding to
beta-catenin and downstream signaling events
Haÿ et al., Mol Cell Biol 2009
:
These data indicate that a previously unrecognized
N-cadherin-axin-LRP5 interaction negatively
regulates Wnt/beta-catenin signaling and is critical in the regulation of osteoblast function, bone formation, and bone mass
Farina et al., PloS one 2009
(Breast Neoplasms...) :
Post-transcriptional
regulation of
cadherin-11 expression by GSK-3 and
beta-catenin in prostate and breast cancer cells
Miller et al., J Cell Biol 1997
:
Consistent with the hypothesis that it is this pool of non-membrane associated beta-catenin that signals in the presence of membrane tethered beta-catenin, overexpression of
cadherin , which binds free beta-catenin,
blocks the axis inducing activity of membrane- tethered
beta-catenin
Sadot et al., Proc Natl Acad Sci U S A 1998
:
We studied the
effect of
N-cadherin , and its free or membrane anchored cytoplasmic domain, on the level and localization of
beta-catenin and on its ability to induce lymphocyte enhancer binding factor 1 ( LEF-1 ) -responsive transactivation