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IDO1 — IL10

Text-mined interactions from Literome

Tu et al., Cell Mol Neurobiol 2005 : IDO is inducible by the cytokine interferon-gamma (IFN-gamma) and has been proposed to mediate the sickness behavior of patients with infectious or other inflammatory diseases.To better understand the neuroendocrine component of cytokine induced sickness behavior we determined the effects of the pro-inflammatory cytokine IFN-gamma and the anti-inflammatory cytokine IL-10 on IDO expression in cells derived from the hypothalamic-pituitary-adrenal axis ( HPA ) : GT1-7 hypothalamic, AtT-20 pituitary, and Y-1 adrenal cells
Romani et al., Blood 2006 : IDO activation by Talpha1 required TLR9 and type I interferon receptor signaling and resulted in interleukin-10 production and generation of regulatory T cells
Chae et al., Arch Pharm Res 2008 (Disease Models, Animal...) : Indomethacin ( Indo ) , a PGE ( 2 ) synthesis inhibitor, greatly inhibited LPS induced production of IL-6 and IL-10 by macrophages from pristane induced lupus mice, while enhanced TNF-alpha ... Indo remarkably inhibited Con A-increased production of IFN-gamma, IL-6, and IL-10 by splenocytes and thymocytes from pristane induced lupus mice
Engela et al., Cell Transplant 2013 : ASCs exerted their suppressive role by expressing IDO , reducing levels of TNF-a, and by inducing the production of IL-10 in effector cells and Tregs