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ITGB1 — MMP1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MMP1
→
Complex of ITGA2-ITGB1
(increases, ITGA2/ITGB1 Activity, MMP1 Activity)
Evidence: Major functions of the alpha2beta1 receptor include the induction of MMP1, % MMP13 and MT1-MMP, as well as activation of proMMP2
Text-mined interactions from Literome
Das et al., Life Sci 2008
(Breast Neoplasms) :
Blocking of
alpha5beta 1 integrin with anti-alpha5 monoclonal antibody
inhibits the fibronectin induced
MMP activation response appreciably
Huhtala et al., J Cell Biol 1995
:
In contrast, peptide V from the heparin binding region, shown previously to stimulate focal contact formation, further
enhanced MMP expression by RSF when present on the substrate with 120FN. RSF expressed
alpha 4 beta 1 integrin , the receptor for CS-1, and the anti-alpha 4 mAb blocked the ability of CS-1 to suppress MMP induction by 120FN