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DUSP1 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database Direct p53 effectors: p53 (tetramer) complex (TP53) → MKP1 (DUSP1) (transcription, activates) Li et al., J Biol Chem 2003*
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Liu et al., Mol Cancer Res 2008 : DUSP1 is controlled by p53 during the cellular response to oxidative stress ... We report here that p53 regulates DUSP1 , a dual-specific threonine and tyrosine phosphatase with stringent substrate specificity for mitogen activated protein kinase ( MAPK )
Shang et al., Oncogene 2010 (Neuroblastoma) : In contrast, DUSP26 overexpression in the SK-N-SH cell line inhibited doxorubicin induced p53 phosphorylation at Ser20 and Ser37, p21, Puma, Bax expression and apoptosis
Begum et al., J Biol Chem 2011 (MAP Kinase Signaling System) : We conclude that PDE3A regulates VSMC growth via two complementary pathways, i.e. PKA catalyzed inhibitory phosphorylation of Raf-1 with resulting inhibition of MAPK signaling and PKA/CREB mediated induction of p21, leading to G0/G1 cell cycle arrest, as well as by increased accumulation of p53 , which induces MKP-1 , p21, and WIP1, leading to inhibition of G1 to S cell cycle progression