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EGFR — IGFBP3

Text-mined interactions from Literome

Takaoka et al., Am J Physiol Gastrointest Liver Physiol 2006 : However, unlike other cell types where IGFBP-3 exerts antiproliferative effects, neither wild-type nor GGG mutant IGFBP-3 alone affected cell proliferation or EGFR activity
Martin et al., J Biol Chem 2009 : SphK1 expression and activity were stimulated by IGFBP-3 approximately 2-fold over 24 h. Silencing of sphingosine 1-phosphate receptor 1 ( S1P1 ) or S1P3, but not S1P2, abolished the effect of IGFBP-3 on EGF stimulated EGFR activation ... These data indicate that potentiation of growth factor signaling by IGFBP-3 in MCF-10A cells requires SphK1 activity and S1P1/S1P3, suggesting that S1P, the product of SphK activity and ligand for S1P1 and S1P3, is the `` missing link '' mediating IGF and EGFR transactivation and cell growth stimulation by IGFBP-3
McIntosh et al., J Biol Chem 2010 (Breast Neoplasms...) : Although IGFBP-3 did not affect EGFR phosphorylation [ Tyr ( 1068 ) ], it was found to modulate receptor internalization and was associated with activation of Rho and subsequent changes in MAPK phosphorylation