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CDK2 — XIC

Text-mined interactions from Literome

Ohnuma et al., Cell 1999 : p27Xic1 , a Cdk inhibitor , promotes the determination of glial cells in Xenopus retina
You et al., Genes Dev 2002 : Unlike degradation of p27 ( kip1 ) in mammalian cells, CDK2 activity is not directly involved in Xic1 degradation and interactions between Xic1 and CDK2/cyclin E are dispensable for Xic1 turnover
Hashiguchi et al., Dev Growth Differ 2007 : Further experiments suggested that p27Xic1 , a key Cdk inhibitor in Xenopus, interacts with XTSC-22
Mochizuki et al., Neural development 2009 : In Xenopus retinogenesis, p27Xic1 , a Xenopus cyclin dependent kinase inhibitor , functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner
Su et al., Proc Natl Acad Sci U S A 1995 : Truncation of the N terminus of Xic-1 increases the IC50 value for cyclin A/Cdk2 50-fold with no effect on the inhibition of cyclin E/Cdk2 or cyclin B/Cdc2.Xic-1 inhibits both single stranded and nuclear DNA synthesis in egg extracts, an effect reversed by proliferating cell nuclear antigen or cyclin E/Cdk2, respectively