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MAPK7 — PDGFB
Text-mined interactions from Literome
Hanada et al., Biol Pharm Bull 1999
:
PDGF-AB stimulated
mitogen activated protein ( MAP ) kinases , and PDGF induced MAP kinase activation was inhibited by genistein
Yoshimata et al., Life Sci 1999
:
Only
MAPK activation
induced by
PDGF-BB was reduced by pretreatment with DHEA, although DHEA did not affect the MAPK activation induced by EGF or bFGF ... These results suggest that DHEA inhibited
MAPK activation
induced by
PDGF-BB via PGE2 overproduction and subsequent cAMP dependent pathway in human male aortic SMCs
Shimizu et al., Cardiovasc Res 1999
:
PDGF-BB also
induced tyrosine phosphorylation and nuclear translocation of
MAPK
Yang et al., Cell Signal 2000
:
Furthermore, we also showed that overexpression of dominant negative mutants of Ras ( RasN17 ) and Raf ( Raf-301 ) completely suppressed MEK1/2 and p42/p44
MAPK activation
induced by OX-LDL and
PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Luo et al., Br J Pharmacol 2000
:
Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44
MAPK activation
induced by LPS and
PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Yang et al., Br J Pharmacol 2001
(MAP Kinase Signaling System) :
7. Overexpression of dominant negative mutants of Ras ( H-Ras-15A ) and Raf ( Raf-N4 ) significantly suppressed MEK1/2 and p42/p44
MAPK activation
induced by OX-LDL and
PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Lin et al., Cell Signal 2001
(MAP Kinase Signaling System) :
Furthermore, overexpression of dominant negative mutants, RasN17 and Raf-301, significantly suppressed p42/p44
MAPK activation
induced by thrombin and
PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Hsu et al., Cell Signal 2001
(MAP Kinase Signaling System) :
Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44
mitogen activated protein kinase ( MAPK ) activation
induced by TNF-alpha and
PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response, indicating that Ras and Raf may be required for activation of these kinases
Cartel et al., Am J Physiol Lung Cell Mol Physiol 2001
(MAP Kinase Signaling System) :
PDGF-BB mediated
activation of
p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation ... Chemical inhibition of Janus kinase, phosphatidylinositol 3-kinase, Src kinase, or tyrosine phosphorylation inhibition of the PDGF beta-receptor ( PDGFR-beta ) did not abrogate
PDGF-BB induced
p42(MAPK) activation or its threonine or tyrosine phosphorylation ... A dominant negative cytoplasmic receptor for hyaluronan mediated motility variant 4 ( RHAMMv4 ), a regulator of MAPKK-MAPK interaction and activation, did not inhibit
PDGF-BB induced
p42(MAPK) activation nor did a construct expressing PDGFR-beta with cytoplasmic tyrosines mutated to phenylalanine ... These results suggest that
PDGF-BB mediated
activation of
p42(MAPK) requires the PDGFR-beta but is independent of its tyrosine phosphorylation
Ricono et al., American journal of physiology. Renal physiology 2002
(MAP Kinase Signaling System) :
PDGF AA and
PDGF BB significantly
increased the activities of phosphatidylinositol 3-kinase (PI 3-K) and
mitogen activated protein kinase ( MAPK )
Lin et al., Cell Signal 2002
(MAP Kinase Signaling System) :
Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44
MAPK activation
induced by thrombin and
PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
De Marchis et al., Blood 2002
:
In addition, PDGF-Ralpha phosphorylation was increased in the presence of bFGF and PDGF, as compared to PDGF alone, whereas
mitogen activated protein kinase phosphorylation was decreased in the
presence of
PDGF-BB and bFGF compared with bFGF alone
Rolny et al., J Biol Chem 2002
:
Heparin potentiated
PDGF-BB induced activation of
mitogen activated protein kinase and protein kinase B ( Akt ) and allowed increased chemotaxis of the CHO 677 cells toward PDGF-BB
Ghosh et al., J Biol Chem 2002
:
Platelet derived growth factor (PDGF)-BB and thrombin ( RTK and GPCR agonists, respectively )
activated p38
MAPK in a time dependent manner in VSMC
Liu et al., Surgery 2002
:
In contrast, C3 did not significantly affect DNA synthesis in
response to
PDGF-AB or activation of
mitogen activated protein kinase , a signaling mediator of PDGF stimulated proliferation
Yang et al., Cell Signal 2002
(Asthma...) :
Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44
MAPK activation
induced by SP and
PDGF-BB
Kotsuji-Maruyama et al., J Dermatol 2002
(Neurofibromatosis 1) :
PDGF-BB furthermore
induced the
mitogen activated protein kinase phosphorylation in NF-derived cells from patients with NF1
Oak et al., Arterioscler Thromb Vasc Biol 2003
(MAP Kinase Signaling System) :
Short-term and long-term treatment of VSMCs with RWPCs markedly reduced
PDGFAB induced production of reactive oxygen species and phosphorylation of p38
MAPK
Rousseau et al., Cell Signal 2006
(MAP Kinase Signaling System) :
Here we show that CXCL12, complement factor 5a ( C5a ), hepatocyte growth factor (HGF) and
platelet derived growth factor (PDGF)-BB , which stimulate cell migration, also
activate p38alpha
MAPK
Muhl et al., Biochem J 2007
:
This leads to the loss of the inhibitory effect of FSAP on
PDGF-BB mediated DNA synthesis and
mitogen activated protein kinase phosphorylation in VSMCs
Lee et al., Cardiovasc Res 2007
(MAP Kinase Signaling System) :
PDGF-BB increased the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, p38
MAPK , and HSP27, which were significantly inhibited by piceatannol and in Syk-knockdown cells
Liu et al., Mol Biol Cell 2008
:
SMOC-2 ablation did not inhibit PDGF induced PDGFbetaR autophosphorylation or
PDGF-BB dependent activation of
mitogen activated protein kinase and Akt kinases, suggesting that SMOC-2 is dispensable for growth factor receptor activation
Roderfeld et al., Liver Int 2009
(Liver Cirrhosis) :
FSAP inhibited
PDGF-BB stimulated p42/p44
MAPK phosphorylation, proliferation and migration of HSC
Chan et al., Molecular vision 2010
:
Furthermore, EGCG is shown to suppress
PDGF-BB induced PDGF-beta receptors, downstream PI3K/Akt, and
MAPK phosphorylation
Seidel et al., Respir Res 2010
(Airway Remodeling) :
PDGF-BB induced the phosphorylation of ERK1/2 and p38
MAPK , but not of JNK ... DMF enhanced the
PDGF-BB induced phosphorylation of p38
MAPK and there by up-regulated the expression of HO-1
Zhong et al., Lung Cancer 2011
(Mesothelioma...) :
PDGF-BB induced proliferation was
suppressed by down-regulation of either Erk1/2, or p38d
MAPK , or C/EBP-a
Zhu et al., Mol Cell Biochem 2013
(MAP Kinase Signaling System...) :
The activations of
mitogen activated protein kinase extracellular signal regulated kinases, Akt, GSK3ß and STAT3
induced by
PDGF-BB were also inhibited in sinomenine treated VSMCs
Lubinus et al., J Biol Chem 1994
:
We investigated the
effects of platelet derived growth factor (PDGF) AA and
PDGF BB on activation of
MAPK in human dermal fibroblasts, and asked whether its activation correlates with proliferative responses of human fibroblasts to PDGF AA and PDGF BB ... Thus both PDGF AA and
PDGF BB are potent
activators of
MAPK in human dermal fibroblasts
Mallat et al., J Clin Invest 1995
(Liver Cirrhosis) :
Analysis of the intermediate steps leading to growth-inhibition by ET-1 revealed that
activation of
mitogen activated protein kinase by serum or
PDGF-BB was decreased by 50 % in the presence of SRTX-C
Graves et al., Proc Natl Acad Sci U S A 1993
:
Stimulation of aortic smooth muscle cells with platelet derived growth factor BB homodimer (
PDGF-BB )
leads to the rapid activation of
mitogen activated protein kinase ( MAPK ) and MAPK kinase ( MAPKK ) ... Compounds that increase cAMP and activate protein kinase A (PKA) -- prostaglandin E2, isoproterenol, cholera toxin, and forskolin -- were found to inhibit the
PDGF-BB induced activation of MAPKK and
MAPK ... Forskolin, but not the inactive analogue 1,9-dideoxyforskolin, inhibited
PDGF-BB stimulated MAPKK and
MAPK activation in a dose dependent manner
Schramek et al., J Cardiovasc Pharmacol 1995
:
Cycloheximide ( 10 micrograms/ml ) inhibited MEK-1 mRNA induction but stimulated p42
MAPK mRNA expression in both the absence and the
presence of ET-1 and/or
PDGF BB
Seewald et al., J Hypertens 1997
:
PDGF-BB induces an increase in intracellular free calcium concentration ( [ Ca2+ ] i ), an activation of
mitogen activated protein ( MAP ) kinase and an increase in DNA synthesis
Hinton et al., Exp Cell Res 1998
:
Using transwell cell-culture chambers, the effect of PDGF-BB ( 10-50 ng/ml ) and fibronectin on components of migration was measured with or without the MAPK pathway inhibitor PD98059 ( 10-30 microM )
MAPK activation of serum starved cells by
PDGF-BB was demonstrated by an immunoprecipitation/kinase assay and by immunohistochemistry using antibody specific for phosphorylated MAPK ...
PDGF-BB ( 10 ng/ml )
stimulated MAPK activity in RPE ( 10 min ) and its nuclear localization ( 1 h ) ... PD98059 inhibited the
activation of
MAPK by
PDGF-BB or serum