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IL10 — JAK2

Text-mined interactions from Literome

Tanuma et al., Blood 2001 : Among cytokines tested, the inhibitory effect of PTPepsilonC is selective to IL-6- and IL-10 induced JAK-STAT signaling
Ding et al., J Immunol 2001 : In this study, we characterized the differential receptor binding specificity, affinity, and Janus kinase-STAT activation of cellular IL-10 ( cIL-10 ) compared with viral IL-10 ( vIL-10 )
To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Conzelmann et al., Biochem Pharmacol 2010 : JAK2 mediated enhancing effects on IL-12p70 but did not inhibit IL-10 release, whereas Tyk2 mediated inhibitory effects on IL-12p70 release in this system
Ngo et al., Nature 2011 (Burkitt Lymphoma...) : The L265P mutant promoted cell survival by spontaneously assembling a protein complex containing IRAK1 and IRAK4, leading to IRAK4 kinase activity, IRAK1 phosphorylation, NF-?B signalling, JAK kinase activation of STAT3, and secretion of IL-6, IL-10 and interferon-ß
Gupta et al., Blood 2012 (Lymphoma, Large B-Cell, Diffuse) : To explore the mechanism by which IL-10 may contribute to an inferior EFS, we investigated the effect of IL-10 on the JAK2 pathway and found that the IL-10/IL-10 receptor complex up-regulated JAK2 signaling ... Neutralizing Ab to IL-10 inhibited constitutive and IL-10 induced JAK2/STAT3 phosphorylation
Pattison et al., J Immunol 2012 : The initial induction of IL-10 was independent of JAK signaling ; however, inhibition of JAKs did reduce IL-10 secretion at later time points