◀ Back to SMAD3

SMAD3 — TFE3

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD3/SMAD4/TFE3 complex (SMAD3-SMAD4-TFE3) → SMAD3/SMAD4/Max complex (SMAD3-SMAD4-MAX) (transcription, activates)
  Hua et al., Proc Natl Acad Sci U S A 1999*, Grinberg et al., J Biol Chem 2003*, Dennler et al., EMBO J 1998*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD3/SMAD4/TFE3 complex (SMAD3-SMAD4-TFE3) → Laminin gamma1 (LAMC1) (transcription, activates) Kawata et al., J Biol Chem 2002*
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: TFE3 (TFE3) → SMAD3/SMAD4 complex (SMAD3-SMAD4) (modification, collaborate)
  Hua et al., Proc Natl Acad Sci U S A 1999*, Grinberg et al., J Biol Chem 2003*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: TFE3 (TFE3) → SMAD3/SMAD4/TFE3 complex (SMAD3-SMAD4-TFE3) (modification, collaborate)
  Hua et al., Proc Natl Acad Sci U S A 1999*, Grinberg et al., J Biol Chem 2003*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD3/SMAD4 complex (SMAD3-SMAD4) → SMAD3/SMAD4/TFE3 complex (SMAD3-SMAD4-TFE3) (modification, collaborate)
  Hua et al., Proc Natl Acad Sci U S A 1999*, Grinberg et al., J Biol Chem 2003*
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TFE3 — SMAD3 (direct interaction, pull down) Grinberg et al., J Biol Chem 2003*
• IRef Biogrid Interaction: TFE3 — SMAD3 (direct interaction, pull down) Hua et al., Proc Natl Acad Sci U S A 1999*
• IRef Hprd Interaction: TFE3 — SMAD3 (in vitro) Hua et al., Proc Natl Acad Sci U S A 1999*, Hua et al., J Biol Chem 2000*, Grinberg et al., J Biol Chem 2003*
• IRef Ophid Interaction: SMAD3 — TFE3 (aggregation, confirmational text mining) Hua et al., J Biol Chem 2000*
• IRef Ophid Interaction: SMAD3 — TFE3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Hua et al., Proc Natl Acad Sci U S A 1999 : Whereas an isolated Smad3 MH1 domain binds to TFE3, TGF-beta receptor mediated phosphorylation of full-length Smad3 enhances its binding to TFE3
Hua et al., J Biol Chem 2000 : Previously, we showed that a similar arrangement between a SBE and an E-box of an element is essential for TGF-beta dependent transcription of the plasminogen activator inhibitor-1 gene ( PAI-1 ) and that TGF-beta induced phosphorylation of Smad3 triggers its association with TFE3