Hausmann et al., J Cell Biol 2000
:
However, neither Bcl-2 nor Bcl-x ( L ) could prevent the in vitro activation of Apaf-1 induced by the addition of exogenous cytochrome c. Hence, rather than sequestering Apaf-1 as proposed by the apoptosome model, Bcl-2-like proteins probably regulate Apaf-1 indirectly by controlling upstream events critical for its activation
Hu et al., Proc Natl Acad Sci U S A 1998
:
Expression of Bcl-XL inhibited the association of Apaf-1 with caspase-9 in mammalian cells