Gene interactions and pathways from curated databases and text-mining

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ELANE — ERBB2

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: ERBB2 → ELANE (decreases, ELANE Translocation)
    Evidence: We then evaluated whether NE reduced ErbB2 expression at the cell surface. Using flow cytometry analysis, we found that NE caused a significant (9.4%) reduction in cell surface ErbB2 expression (Fig. 5). These results support the concept that NE cleaves cell surface ErbB2.
  • OpenBEL Selventa BEL large corpus: ERBB2 → ELANE (decreases, ERBB2 Activity)
    Evidence: We then evaluated whether NE reduced ErbB2 expression at the cell surface. Using flow cytometry analysis, we found that NE caused a significant (9.4%) reduction in cell surface ErbB2 expression (Fig. 5). These results support the concept that NE cleaves cell surface ErbB2.