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EGF — POT1

Text-mined interactions from Literome

Lu et al., Exp Cell Res 2000 : We demonstrate that NGF and EGF induce Rap1 activation in PC12-Shb cells, while FGF-2 fails to do so
Wu et al., J Neurosci 2001 (MAP Kinase Signaling System) : Although both epidermal growth factor (EGF) and NGF caused transient activation of Ras, only NGF induced the activation of Rap1
Ohba et al., EMBO J 2003 : Epidermal growth factor (EGF) activates Ras and Rap1 at distinct intracellular regions
Jenei et al., Exp Cell Res 2005 : E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor ... Remarkably, we found that EGF induced activation of the p21Ras related GTPase Rap1 was also sensitized in NIH3T3/EGFR-e3B1 cells ... Thus, in NIH3T3/EGFR-e3B1 cells, maximal EGF induced activation of Rap1 occurs with a dose of EGF much lower than in NIH3T3/EGFR cells ... We also report that overexpression of e3B1 in NIH3T3/EGFR cells renders EGF induced activation of Rap1 completely dependent on Src tyrosine kinases but not on c-Abl ... Accordingly, we propose that overexpression of e3B1 in NIH3T3/EGFR cells leads to mobilization of Src tyrosine kinases that participate in EGF induced activation of Rap1 and inhibition of cell proliferation
Okada et al., J Biol Chem 1997 : Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex