◀ Back to STAT1

IL21 — STAT1

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Lee et al., J Exp Med 1999 : Interestingly, interleukin (IL)-7 selectively activated STAT1 and induced MHC class I in mature T but not B cells
Strengell et al., J Immunol 2003 : Similarly, IL-21 induced the binding of STAT1 , STAT3, and STAT4 to these elements ... IL-15- and IL-21 induced STAT1 and STAT4 activation was verified by immunoprecipitation with anti-phosphotyrosine Abs followed by Western blotting with anti-STAT1 and anti-STAT4 Abs. IL-18 was not able to induce the binding of STATs to IFN-gamma gene regulatory sites
Habib et al., J Allergy Clin Immunol 2003 : As expected for cytokines that use gammac, recent studies indicate that IL-21 induces Janus kinase 1 (JAK1) and JAK3 activation to initiate signal transduction, but unlike these other gammac dependent cytokines, which predominantly activate signal transducer and activator of transcription 5 ( STAT5 ), IL-21 preferentially activates STAT1 and STAT3
Wendt et al., Immunology 2007 : Intracellular analysis of signal transducer and activator of transcription ( STAT ) proteins revealed that IL-21 by itself induces phosphorylation of STAT1 and STAT3 in CD56 ( dim ) NK cells, and to an even higher degree in CD56 ( bright ) NK cells
Rahman et al., FEBS Lett 2007 : Furthermore IL-21 and IL-21iso similarly activated STAT1 and STAT3
Gowda et al., Blood 2008 : In addition to its proapoptotic effect, IL-21 promoted STAT1 and STAT5 phosphorylation in natural killer cells with concurrent enhanced antibody dependent cellular cytotoxicity against rituximab coated CLL cells in vitro
Avery et al., J Exp Med 2010 : Interleukin (IL)-21 activates STAT1 and STAT3 and has emerged as a potent regulator of B cell differentiation
Liu et al., Cell Immunol 2011 : Further analysis indicated that IL-21 induced phosphorylation of STAT1 , STAT3 and STAT5 in activated naïve CD4 ( + ) T cells
Uzel et al., J Allergy Clin Immunol 2013 (Genetic Diseases, X-Linked...) : STAT1 phosphorylation in response to IFN-?, IL-6, and IL-21 was increased and prolonged