Gene interactions and pathways from curated databases and text-mining

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IL4 — MTX1

Text-mined interactions from Literome

Hildner et al., Clin Exp Immunol 1999 (Arthritis, Rheumatoid) : Interestingly, MTX did not enhance IL-4 production when present during restimulation of effector CD45RO T cells, although it still suppressed TNF production
Morita et al., Scand J Rheumatol 2006 (Arthritis, Rheumatoid) : The effect of MTX on intracellular expression of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) , and cell surface expression of signalling lymphocytic activation molecule ( SLAM ) from freshly isolated peripheral blood mononuclear cells ( PBMCs ), and after in vitro culture with or without MTX, was analysed with flow cytometry in 18 patients with RA and 20 healthy controls
Hou et al., J Zhejiang Univ Sci B 2011 (Arthritis, Experimental) : Neither MTX nor BSO had an effect on the mRNA expressions of IL-4 , transforming growth factor ß ( TGF-ß ), and tumor necrosis factor-a (TNF-a) in the spleen
Meyer et al., J Rheumatol 1993 (Arthritis, Rheumatoid) : MTX had no effect on interleukin 1 stimulated production of prostaglandin E, hyaluronic acid and collagenase