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EPHB2 — LDLR

Text-mined interactions from Literome

Kong et al., Nat Med 2004 (Hypercholesterolemia) : Using human hepatoma cells, we show that BBR upregulates LDLR expression independent of sterol regulatory element binding proteins, but dependent on ERK activation
Abidi et al., Arterioscler Thromb Vasc Biol 2005 (Carcinoma, Hepatocellular...) : Using different reporter constructs, we demonstrate that BBR affects LDLR mRNA stability entirely through 3 ' untranslated region ( UTR ) in an ERK dependent manner, and this stabilizing effect is more prominent in liver derived cells than nonhepatic cell lines
Lu et al., J Agric Food Chem 2008 (Hypercholesterolemia) : Collectively, these new findings identify gossypin as a new hypocholesterolemic agent that up-regulates LDLR expression independent of SREBP-2 but is dependent on ERK activation
Xiong et al., PLoS Pathog 2009 (Ehrlichiosis) : Up-regulation of LDLR mRNA by A. phagocytophilum was also inhibited by the MEK inhibitor ; however, it was unclear whether ERK activation is required for LDLR mRNA up-regulation by A. phagocytophilum
Duan et al., J Biol Chem 2012 : However, PPAR? activation by ligands or ERK1/2 inhibitors induced hepatic LDLR expression
Kumar et al., J Lipid Res 1997 : Moreover, pretreatment of cells with calphostin C inhibited TPA mediated ERK activation and LDL receptor mRNA induction in a dose dependent fashion