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MDM2 — SMAD4

Text-mined interactions from Literome

Yam et al., Cancer Res 1999 : MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins ... Here we show that MDM2 and the structurally related protein MDMX can inhibit the transcriptional activity of ectopically expressed SMAD1, SMAD2 , SMAD3, and SMAD4 ... Here we show that MDM2 and the structurally related protein MDMX can inhibit the transcriptional activity of ectopically expressed SMAD1, SMAD2, SMAD3, and SMAD4
Chang et al., Clin Cancer Res 2013 (Carcinoma, Pancreatic Ductal...) : We further found that MDM2 and Bmi-1 were overexpressed in the tumorigenic HPDE cells and that Bmi-1 overexpression was regulated by Smad4