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CD4 — FAS
Text-mined interactions from Literome
Rich et al., J Virol 1999
:
Antiretroviral cytolytic T-lymphocyte nonresponsiveness :
FasL/Fas mediated inhibition of
CD4 ( + ) and CD8 ( + ) antiviral T cells by viral antigen positive veto cells
Desbarats et al., Proc Natl Acad Sci U S A 1999
:
In vivo experiments in hen egg lysozyme (HEL) T cell receptor transgenic mice show that CD4 ( + ) T cells from HEL-naïve mice are killed by Fas ligation, but
CD4 ( + ) T cells from long-term HEL exposed mice are
costimulated by
Fas ligation
Tateyama et al., Blood 2000
:
In the present study, we demonstrate that
CD4XL in purified T cells not only
led to
Fas up-regulation but also primed CD4 T cells to express FasL upon CD3 stimulation and rendered the T cells susceptible to Fas mediated apoptosis
Cloyd et al., Curr Mol Med 2001
(HIV Infections...) :
HIV binding to, and signaling through,
CD4 and chemokine receptor molecules on resting CD4 lymphocytes and other cell types [ which extensively occurs as the rare, productively infected cells ( ie : infected cells producing virus ) migrate among other cells through the lymphoid tissues back into the blood ]
induces upregulation of L-selectin and
Fas
Demir et al., Leuk Res 2003
(Melanoma...) :
Expression of
CD95 ( Apo-1/Fas ) and CD45RO on monocytes increased significantly on the 5th day, and
CD4 expression on monocytes
increased significantly on the 14th day
Saff et al., J Immunol 2004
(Neoplasms, Experimental) :
However, in the context of an extensive tumor burden, chronic stimulation of such
CD4 ( + ) T cells often
leads to the up-regulation of both
Fas and Fas ligand, and coexpression of these molecules can potentially result in activation induced cell death and the subsequent loss of effector activity
Mukherjee et al., J Leukoc Biol 2005
:
The enhanced
CD4 ( + ) T cell death with a suppressive dose of Con A is dependent on excess H ( 2 ) O ( 2 ) and nitric oxide but is
independent of
Fas and caspase activity
O'Rourke et al., Obes Surg 2005
(Obesity, Morbid) :
These data suggest both
CD4+ and CD8+ T-cell compartments, as well as the
regulation of
CD95 expression on CD8+ T-cells, as targets for further study into obesity 's effects on the immune system
Barral et al., J Autoimmun 2006
(Diabetes Mellitus, Type 1...) :
Not only absence of MHC-I and
Fas upregulation, but also resistance to cytokine induced killing of beta-cells and a complete lack of CXCL-10 ( IP10 ) production in islets
led to a lack of islet infiltration and impaired activation of autoaggressive
CD4 ( + ) and CD8 ( + ) T-cells in these mice
Saint Fleur et al., Blood 2009
:
Finally, we demonstrated that activated but not resting
CD4 ( + ) T cells with targeted deletion of a Cyclon allele show
reduced AICD and expression of
Fas , indicating a critical role of Cyclon in Fas expression in activated T cells
Wen et al., Eur J Immunol 2011
(Diabetes Mellitus, Type 1) :
We found that
CD4 ( + ) T lymphocytes
require Fas expression in the recipients ' target cells to induce diabetes
Weant et al., Cell Immunol 2011
(Chronic Disease...) :
Loss of both Bim and
Fas also
increased the number of virus-specific
CD4 ( + ) T cells found in the lymph nodes compared to the parental genotypes or wildtype mice
Yao et al., J Interferon Cytokine Res 2012
(Asthma) :
This research has revealed an alternative mechanism in asthma that involves low doses of IFN-?, which attenuate airway inflammation through enhancing
Fas/FasL induced
CD4 ( + ) T cell apoptosis
Oyaizu et al., Blood 1994
:
Cross linking of
CD4 molecules
upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion ... We show here that cross linking of
CD4 molecules, induced either by anti-CD4 monoclonal antibody ( MoAb ) Leu3a or by human immunodeficiency virus-1 ( HIV-1 ) envelope protein gp160,
upregulates Fas Ag expression as well as Fas mRNA in normal lymphocytes ... Both INF-gamma and TNF-alpha were found to contribute to Fas Ag upregulation and both anti-IFN-gamma and anti-TNF-alpha antibodies blocked
CD4XL induced
Fas Ag upregulation and lymphocyte apoptosis ... These findings strongly suggest that aberrant cytokine secretion
induced by
CD4XL and consequent upregulation of
Fas Ag expression might play a critical role in triggering peripheral T-cell apoptosis and thereby contribute to HIV disease pathogenesis
Oyaizu et al., Adv Exp Med Biol 1995
(HIV Infections) :
Both these cytokins contributed to Fas Ag up-regulation and antibodies to TNF-alpha and INF-tau abrogated
CD4XL induced
Fas up-regulation and T-cell apoptosis
Gehri et al., AIDS 1996
(HIV Infections) :
To analyse the
role of the apoptosis inducing
Fas receptor in the depletion of
CD4+ and CD8+ T cells in HIV infected individuals
Oyaizu et al., J Immunol 1997
(HIV Infections) :
In purified monocytes, CD4XL results in FasL expression ; in purified CD4+ T cells, however,
CD4XL upregulates
Fas but not FasL expression
Shustov et al., J Immunol 1998
(Acute Disease...) :
Donor
CD4+ T cell activation in the absence of CD8+ T cell activation
results in an autoantibody mediated response, no significant
Fas/FasL up-regulation, impaired elimination of autoreactive B cells, and persistent humoral autoimmunity
Casella et al., J Virol 1999
:
We found that
Fas cross linking
caused a decrease in the number of HIV infected Jurkat T cells and
CD4 ( + ) peripheral blood leukocytes ( PBLs )