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HMOX1 — NOS2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: NOS2 → HMOX1 (decreases, HMOX1 Activity, NOS2 Activity)
  Evidence: where CO takes over the roles of NO under conditions of oxidative stress (Maines, 1997). Therefore, HO activity is important in controlling the activity of heme proteins, such as cytochromes P450, COX, guanylyl cyclase, and NOS, not only at the level of the intracellular heme pool available for the apo-heme proteins (Kappas and Drummond, 1986) but possibly also at the level of HO's downstream effector molecule CO by interactions with the heme group (Haider et al., 2002).

Text-mined interactions from Literome

Datta et al., J Am Soc Nephrol 1999 (Glomerulonephritis...) : Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis
Wang et al., Am J Physiol Gastrointest Liver Physiol 2001 (Colitis, Ulcerative) : Furthermore, the reduction of HO-1 expression by SnMP also enhanced reactive oxygen species and iNOS expression, both of which were dramatically increased after the TNBS enema
Datta et al., Kidney Int 2002 (Anti-Glomerular Basement Membrane Disease) : iNOS inhibition reduced glomerular HO-1 levels without altering the inflammatory response to anti-GBM antibody induced injury
Coito et al., Transplantation 2002 (Obesity...) : Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury ... HO-1 gene transfer significantly prolongs survival of steatotic orthotopic liver transplants, depresses macrophage infiltration, suppresses local expression of inducible nitric oxide synthase , and modulates pro- and antiapoptotic pathways
Wei et al., J Pathol 2003 (Liver Cirrhosis) : Induction of HO-1 may be mediated partially by iNOS
André et al., FEBS Lett 2003 : While no effect was observed in the presence of iNOS activity alone, a synergistic effect on HO-1 expression was observed in the presence of iNOS expression and GSH depletion
Vicente et al., J Pharmacol Exp Ther 2003 (Inflammation) : Up-regulation of HO-1 by hemin administration resulted in inhibition of nitric-oxide synthase-2 activity, cellular infiltration into the air pouch exudate, and plasmatic exudation
Oh et al., Biochem Biophys Res Commun 2004 : Because HO-1 expression can suppress iNOS expression, we investigated whether HA could suppress iNOS expression by affecting HO-1 expression in murine RAW 264.7 macrophages stimulated with IFN-gamma plus LPS
Yang et al., J Biomed Sci 2004 : Heme oxygenase-1 attenuates interleukin-1beta induced nitric oxide synthase expression in vascular smooth muscle cells ... To characterize the role of HO-1 in the vascular inflammatory response, we examined the effect of HO-1 on the expression of inducible nitric oxide synthase (iNOS) induced by interleukin-1beta (IL-1beta) in rat vascular smooth muscle cells ( VSMCs ) ... Western blot analysis demonstrated that IL-1beta induced iNOS expression was significantly reduced by hemin cotreatment or adenovirus mediated HO-1 gene transfer ... Scavenging carbon monoxide ( CO ), one of the by-products of heme degradation by HO-1, significantly attenuated HO-1 mediated suppression of iNOS gene induction as revealed by Northern blot analysis
Maeshima et al., Biochem Pharmacol 2005 (Respiratory Distress Syndrome, Adult...) : HA pretreatment markedly induced HO-1 in pulmonary epithelial cells, and ameliorated the lung injury induced by HSR as judged by the improvement of histological changes, while it decreased TNF-alpha and inducible nitric oxide synthase gene expression, lung wet weight to dry weight ratio, and myeloperoxidase activity
Lee et al., Free Radic Biol Med 2005 (Body Weight) : The iNOS inhibitor aminoguanidine significantly suppressed the induction of HO-1
Minamoto et al., J Exp Med 2005 (Bronchiolitis Obliterans) : Compared with wild-type allografts, expression of inducible NO synthase (iNOS) , which promotes the influx of cytoeffector leukocytes and airway graft rejection, was strikingly reduced by either enhanced expression of Hmox-1 or exogenous CO. Hmox-1/CO decreased nuclear factor (NF)-kappaB binding activity to the iNOS promoter region and iNOS expression
Huang et al., Acta Anaesthesiol Scand 2005 (Lung Diseases...) : We sought to investigate the role of heme oxygenase-1 (HO-1) on this HBO inhibition of iNOS induction and acute lung injury in septic rat lungs ... Induction of HO-1 , by HBO and/or hemin, significantly attenuated this LPS induced iNOS expression and acute lung injury
Chen et al., Eur J Pharmacol 2005 : To address the involvement of heme oxygenase-1 induction in iNOS inhibition, heme oxygenase-1 antisense oligodeoxynucleotide was used
Datta et al., Nephrol Dial Transplant 2006 (Disease Models, Animal...) : Regulatory effects of inducible nitric oxide synthase on cyclooxygenase-2 and heme oxygenase-1 expression in experimental glomerulonephritis
Ahmad et al., Cell Mol Biol Incl Cyto Enzymol 2005 (Diabetes Mellitus...) : Therefore, overexpression of HO-1 may mediate an increase in eNOS and a decrease in iNOS , potentially contributing to restoration of vascular responses in diabetic rats
Park et al., Biochem Biophys Res Commun 2006 (Rosacea) : Inhibition of HO-1 activity by tin protoporphyrin, a specific HO-1 inhibitor, suppressed the URCE induced reductions in the production of NO and PGE ( 2 ) as well as the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2)
Xia et al., Injury 2007 (Disease Models, Animal...) : Intratracheal administration of LPS induced significant expressions of the inducible isoform of NO synthase (iNOS) and HO-1 , while both haemin pretreatment and SNP treatment increased the expression of HO-1 and prevented the expression of iNOS
Montcalm-Smith et al., Aviat Space Environ Med 2007 (Decompression Sickness...) : HO-1 and HSP-70 increased in the brain, and HO-1, Egr-1, and iNOS increased in the lungs of animals with DCS
Benallaoua et al., Arthritis Rheum 2007 (Arthritis, Experimental...) : In contrast, NO production in serum and inducible NO synthase expression in chondrocytes were not affected by HO-1 induction
Ashino et al., Mol Immunol 2008 : Negative feedback regulation of lipopolysaccharide induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages
Li Volti et al., Transplant Proc 2007 (Disease Models, Animal...) : Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemia-reperfusion injury
Kim et al., Biomed Pharmacother 2008 : Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages ... Collectively, we provide evidence to support the important role of HO-1 in inhibition of NO production and iNOS expression by curcumin even at low concentrations
Manalo et al., Biochem J 2008 : OG, unlike HS, induced a sharp increase in HO-1 ( haem oxygenase-1 ) transcription at 4 h, which declined rapidly within 24 h, whereas modest increases in iNOS [ inducible ( nitric oxide synthase ) ] and constitutive NOS [ eNOS ( endothelial NOS ) ] were detected over the control
Tsoyi et al., Cell Signal 2008 : Additionally, silencing HO-1 by siRNA prevented CKD712 from inhibiting iNOS expression but not COX-2
Choi et al., Gastroenterology 2008 (Diabetes Mellitus, Experimental...) : Induction of HO-1 by hemin decreased reactive oxygen species, rapidly restored Kit and neuronal nitric oxide synthase expression, and completely normalized gastric emptying in all mice
Hu et al., J Ethnopharmacol 2009 : A specific inhibitor of HO-1 , Zn ( II ) protoporphyrin IX, blocked the suppression of NO production, cytokines release and iNOS expression by brazilin
Suliburk et al., Am J Physiol Gastrointest Liver Physiol 2009 (Drug-Induced Liver Injury...) : HO-1 inhibition attenuated ketamine induced hepatoprotection and downregulation of iNOS and COX-2 protein
Saw et al., Biochem Pharmacol 2010 (Inflammation) : The combinations were also found to suppress iNOS , COX-2, 5-lipoxygenase (5-LOX) and cPLA(2) but induce HO-1
Lee et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009 : We examined our hypothesis whether inhibitory effects of aprotinin on cytokine induced inducible nitric oxide synthase (iNOS) expression ( IL-1beta plus TNF-alpha ), reactive oxygen species ( ROS ) generation, and vascular smooth muscle cell ( VSMC ) proliferation were due to HO-1 induction in rat VSMCs. Aprotinin induced HO-1 protein expression in a dose dependent manner, which was potentiated during inflammatory condition
Kim et al., J Periodontol 2009 : The anti-inflammatory role of heme oxygenase-1 in lipopolysaccharide and cytokine stimulated inducible nitric oxide synthase and nitric oxide production in human periodontal ligament cells ... HO-1 inhibitor and HO-1 small interfering RNA ( siRNA ) attenuated the LPS- and cytokine stimulated NO release and iNOS and HO-1 expression ... Collectively, these data suggested that HO-1 inhibition blocked LPS- and proinflammatory cytokine stimulated iNOS expression and NO production in PDL cells via a mechanism that involves p38, ERK, PI3K, NF-kappaB, and PKC-delta
Okamoto et al., Journal of clinical biochemistry and nutrition 2010 : iNOS dependent 8-nitro-cGMP formation and HO-1 induction were identified in Salmonella infected mice
Pi et al., J Periodontal Res 2010 : Heme oxygenase-1 mediates nicotine- and lipopolysaccharide induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells
Krause et al., Nitric Oxide 2010 : The furoxan CAS 1609 stimulated growth, decreased iNOS-mRNA expression and transiently increased haem oxygenase-1 (HO-1)-mRNA without releasing considerable amounts of NO. 1H- [ 1,2,4 ] Oxadiazolo [ 4,3,-alpha ] quinoxalin-1-one ( ODQ ) attenuated the action of CAS 1609
Lin et al., Carcinogenesis 2010 (Breast Neoplasms...) : Induction of heme oxygenase-1 in macrophages reduced MDA-CM induced iNOS/NO , JNK and NF-?B activations in accordance with inhibiting VEGF-A and MMP-9 gene expressions by MDA-MB-231 cells via Transwell assays
Kachadourian et al., Free Radic Biol Med 2011 : They have been reported to inhibit the synthesis of the inducible nitric oxide synthase and to induce the expression of heme oxygenase-1
Kil et al., Journal of clinical biochemistry and nutrition 2012 : Heme oxygenase-1 expression via activation of nuclear factor-erythroid 2-related factor 2 inhibits nitric oxide production and inducible nitric oxide synthase expression in activated macrophages
Joe et al., J Pharmacol Exp Ther 2012 (Vascular Diseases) : Danshen and Sal B both induced the expression of heme oxygenase-1 (HO-1) and inhibited nitric oxide ( NO ) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS) activated RAW 264.7 cells
Park et al., Neurochem Int 2012 : We next demonstrated that ar-turmerone induced HO-1 and Nrf-2 activation suppressed the activation of neuroinflammatory molecules in LPS induced microglial cells, and that down-regulation of HO-1 signals was sufficient to induce the expression of iNOS , COX-2 and ROS production in microglial cells
Cheng et al., J Sci Food Agric 2013 (Inflammation) : A specific inhibitor of HO-1 , zinc ( II ) protoporphyrin IX, inhibited the suppression of iNOS and COX-2 expression by PV
Choi et al., Nitric Oxide 2013 : Furthermore, the results from an experiment involving a specific siRNA and chemical inhibitors for HO-1 showed that the PG201 mediated increase of the HO-1 protein contributed to the suppression of inducible nitric oxide synthase (iNOS) and nitrite production stimulated by lipopolysaccharide
Hauser et al., Am J Physiol 1996 (Hypotension) : Arsenite pretreatment resulted in expression of HSP 70 mRNA and of HSP 70 and heme oxygenase-1 proteins, inhibition of LPS mediated iNOS mRNA induction, reversal of the LPS induced hyporesponsiveness to norepinephrine ex vivo in isolated mesenteric arteries, and attenuation of LPS induced hypotension in vivo
Kitamura et al., Life Sci 1998 : Immunocytochemistry showed that LPS-treatment induced iNOS-immunoreactivity predominantly in microglia, while this treatment induced HO-1-immunoreactivity in both microglia and astrocytes
Hildebrandt et al., Strahlenther Onkol 1998 (Granulomatous Disease, Chronic...) : Furthermore, the suppression of iNOS activity could be due to the increase in the stress protein HO-1 by low dose radiotherapy