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AKT2 — PLCG1
Text-mined interactions from Literome
Hong et al., Biochem Biophys Res Commun 2001
:
In addition,
PLC-gamma1 activation was
independent of
Akt/protein kinase B ( Akt/PKB )
Kwon et al., J Cell Biol 2003
:
Expression of the PH-EF construct blocked endogenous
PLCgamma1 binding to the IR and
inhibited insulin dependent phosphorylation of mitogen activated protein kinase ( MAPK ), but not
AKT
Nguyen et al., J Biochem Mol Biol 2007
(MAP Kinase Signaling System) :
By contrast, Overexpression of
WT-PLC-gamma1 exhibited sustained NGF induced MAPK activation, and
triggered transient
Akt activation resulting in profound inhibition of neurite outgrowth
Zheng et al., J Neurochem 2008
(Ion Channel Gating) :
Although previous studies suggested the
roles of mitogen activated protein kinase,
phospholipase C-gamma mediated intracellular calcium ( [ Ca2+ ] i ) increase, and extracellular calcium influx in regulating
Akt activation, the cellular mechanisms are largely unknown
Maffucci et al., PloS one 2009
:
Finally we show that PI3K dependent
PLCgamma1 activation
regulates FGF-2 mediated phosphorylation of
Akt at its residue Ser473, determined by Western blotting analysis
Coso et al., PloS one 2012
:
Furthermore, activation of
PI3K/Akt by VEGF-C/VEGFR-3
resulted in phosphorylation of P70S6K, eNOS,
PLC?1 , and Erk1/2