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ANGPT2 — FGF2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Angiopoietin receptor Tie2-mediated signaling: FGF2 (FGF2) → Ang2 (ANGPT2) (transcription, activates) Krikun et al., Biochem Biophys Res Commun 2000, Fujiyama et al., Circ Res 2001, Otani et al., Diabetes 2001
  Evidence: mutant phenotype, assay, reporter gene

Text-mined interactions from Literome

Kuroda et al., J Invest Dermatol 2001 (Psoriasis) : Vascular endothelial growth factor and basic fibroblast growth factor , which were overexpressed in involved psoriasis skin, enhanced angiopoietin 2 and Tie2 expression in dermal microvascular endothelial cell cultures
Skaletz-Rorowski et al., Basic Res Cardiol 2004 : Ang II induces an AT1 receptor dependent expression of bFGF and also upregulates the FGF-R1 and HSPG expression which is suppressed by losartan, the AT1 receptor blocker
Katz et al., Am J Obstet Gynecol 2009 : Only Ang-2 gene transfer resulted in increased fetal weight, and only Ang-2 and basic fibroblast growth factor resulted in a change in placental weight
Fujii et al., In Vitro Cell Dev Biol Anim 2010 : Furthermore, FGF-2 increased the expression of Ang-2 in endothelial cells
Tang et al., Biochem Pharmacol 2011 : The purpose of this study was to determine the signaling cascades underlying the Ang II-induced transcriptional activation of FGF2 in neonatal rat cardiomyocytes