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IL6 — RAC1
Text-mined interactions from Literome
Faruqi et al., Proc Natl Acad Sci U S A 2001
:
Rac1 mediates STAT3 activation by autocrine
IL-6 ... Rac V12 expression results in the induction of the IL-6 and IL-6 receptor genes and neutralizing antibodies directed against the
IL-6 receptor block
Rac1 induced STAT3 activation ...
Rac V12 expression
results in the induction of the
IL-6 and IL-6 receptor genes and neutralizing antibodies directed against the IL-6 receptor block Rac1 induced STAT3 activation
Montaner et al., Blood 2004
(Sarcoma, Kaposi) :
Inhibition of
Rac1 blocked vGPCR induced transcription and secretion of KS cytokines, including
interleukin-6 (IL-6) , IL-8, and growth regulated oncogene alpha ( GROalpha ), in vitro and reduced vGPCR tumorigenesis in vivo