◀ Back to MCM6
MCM4 — MCM6
Pathways - manually collected, often from reviews:
-
BioCarta cdk regulation of dna replication:
ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG)
→
ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7)
(modification, collaborate)
-
BioCarta cdk regulation of dna replication:
ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG)
→
KITL (KITLG)
(modification, collaborate)
-
BioCarta cdk regulation of dna replication:
ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7)
→
KITL (KITLG)
(modification, collaborate)
-
BioCarta cdk regulation of dna replication:
ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7)
→
Mcm2-7 complex (MCM2-MCM3-MCM4-MCM5-MCM6-MCM7)
(modification, collaborate)
-
BioCarta cdk regulation of dna replication:
ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7)
→
ORC/CDC6/CDT1 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1)
(modification, collaborate)
-
BioCarta cdk regulation of dna replication:
Mcm2-7 complex (MCM2-MCM3-MCM4-MCM5-MCM6-MCM7)
→
ORC/CDC6/CDT1 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1)
(modification, collaborate)
-
BioCarta cdk regulation of dna replication:
ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG)
→
ORC/CDC6/CDT1/Cyclin E/CDK2/p27 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-CCNE1-CDK2-CDKN1B)
(regulation of DNA replication initiation, activates)
-
KEGG Cell cycle:
Complex of ORC1-ORC2-ORC3-ORC4-ORC5-ORC6
→
Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7
(protein-protein, binding/association)
-
KEGG Cell cycle:
CDC45
→
Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7
(protein-protein, binding/association)
-
KEGG Cell cycle:
Complex of CDC7-DBF4
→
Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7
(protein-protein, phosphorylation)
-
Reactome Reaction:
MCM4
→
MCM6
(direct_complex)
-
WikiPathways Cell Cycle:
CDC7/DBF4
→
Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-MCM8-MCM9-MCM10
(activation)
-
WikiPathways Cell Cycle:
CDC45
→
Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-MCM8-MCM9-MCM10
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
MCM4
—
MCM6
Yu et al., J Mol Biol 2004*
-
IRef Bind_translation Interaction:
MCM4
—
MCM6
(two hybrid)
Yu et al., J Mol Biol 2004*
-
IRef Bind_translation Interaction:
MCM4
—
MCM6
(cross-linking study)
Yu et al., J Mol Biol 2004*
-
IRef Bind_translation Interaction:
MCM4
—
MCM6
(coimmunoprecipitation)
Yu et al., J Mol Biol 2004*
-
IRef Biogrid Interaction:
MCM4
—
MCM6
(physical association, affinity chromatography technology)
You et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
MCM4
—
MCM6
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
IRef Biogrid Interaction:
MCM4
—
MCM6
(physical association, affinity chromatography technology)
Kristensen et al., Nat Methods 2012
-
IRef Biogrid Interaction:
MCM4
—
MCM6
(direct interaction, two hybrid)
Kneissl et al., J Mol Biol 2003
-
IRef Biogrid Interaction:
MCM4
—
MCM6
(direct interaction, pull down)
Yabuta et al., Genes Cells 2003*
-
IRef Biogrid Interaction:
MCM4
—
MCM6
(physical association, affinity chromatography technology)
Ishimi et al., J Biol Chem 1996
-
MIPS CORUM MCM4-MCM6-MCM7 complex:
MCM4-MCM6-MCM7 complex complex (MCM4-MCM6-MCM7)
Ishimi et al., J Biol Chem 1997*
-
MIPS CORUM MCM2-MCM4-MCM6-MCM7 complex:
MCM2-MCM4-MCM6-MCM7 complex complex (MCM2-MCM4-MCM6-MCM7)
Ishimi et al., J Biol Chem 1997*
-
MIPS CORUM MCM complex:
MCM complex complex (MCM2-MCM3-MCM4-MCM5-MCM6-MCM7)
Ishimi et al., J Biol Chem 1996
-
MIPS CORUM Emerin complex 24:
Emerin complex 24 complex (BANF2-C1QBP-EMD-HIST1H1A-HIST1H3B-HIST1H3C-HIST1H3A-HIST1H3F-HIST1H3G-HIST1H3D-HIST1H3E-HIST1H3J-HIST1H3H-HIST1H3I-HNRNPU-LMNA-LMNB1-MCM2-MCM4-MCM6-NMI-RB1-RBL2-SAP130)
Holaska et al., Biochemistry 2007
-
IRef Corum Interaction:
Complex of 73 proteins
(association, ion exchange chromatography)
Holaska et al., Biochemistry 2007
-
IRef Corum Interaction:
Complex of MCM6-MCM7-MCM4
(association, chromatography technology)
Ishimi et al., J Biol Chem 1997*
-
IRef Dip Interaction:
Complex of MCM4-MCM7-MCM6-CDC45-MCM3-MCM5-L3MBTL1-MCM2-PCNA
(anti tag coimmunoprecipitation)
Gurvich et al., Proc Natl Acad Sci U S A 2010
-
IRef Hprd Interaction:
Complex of 50 proteins
(in vivo)
Ishimi et al., J Biol Chem 1996
-
IRef Hprd Interaction:
Complex of 50 proteins
(in vivo)
Tan et al., EMBO J 2006
-
IRef Hprd Interaction:
MCM4
—
MCM6
(in vivo)
Kneissl et al., J Mol Biol 2003, Yabuta et al., Genes Cells 2003*, Tan et al., EMBO J 2006
-
IRef Hprd Interaction:
MCM4
—
MCM6
(two hybrid)
Kneissl et al., J Mol Biol 2003, Yabuta et al., Genes Cells 2003*, Tan et al., EMBO J 2006
-
IRef Hprd Interaction:
MCM4
—
MCM6
(in vitro)
Kneissl et al., J Mol Biol 2003, Yabuta et al., Genes Cells 2003*, Tan et al., EMBO J 2006
-
IRef Intact Interaction:
Complex of MCMBP-MCM4-MCM6-MCM3-MCM7
(association, anti bait coimmunoprecipitation)
Sakwe et al., Mol Cell Biol 2007
-
IRef Intact Interaction:
Complex of MCM3-HIST1H4A-DAXX-MCM7-MCM5-MCM4-MCM6-MCM2
(association, tandem affinity purification)
Saade et al., Proteomics 2009
-
IRef Intact Interaction:
Complex of 15 proteins
(association, tandem affinity purification)
Saade et al., Proteomics 2009
-
IRef Intact Interaction:
Complex of MCM7-MCM6-ORC2-MCM4
(association, coimmunoprecipitation)
Schaarschmidt et al., Nucleic Acids Res 2002
-
IRef Intact Interaction:
Complex of 31 proteins
(association, pull down)
Nguyen et al., PloS one 2012
-
IRef Intact Interaction:
Complex of 24 proteins
(association, affinity chromatography technology)
Karmakar et al., EMBO J 2010
-
IRef Intact Interaction:
Complex of 21 proteins
(association, tandem affinity purification)
Piwko et al., EMBO J 2010
-
IRef Intact Interaction:
Complex of 19 proteins
(association, pull down)
Jäger et al., Nature 2012
-
IRef Intact Interaction:
Complex of 20 proteins
(association, affinity chromatography technology)
Karmakar et al., EMBO J 2010
-
IRef Intact Interaction:
Complex of 29 proteins
(association, anti tag coimmunoprecipitation)
Jäger et al., Nature 2012
-
IRef Intact Interaction:
Complex of 185 proteins
(association, cross-linking study)
Humphries et al., Science signaling 2009
-
IRef Intact Interaction:
Complex of 168 proteins
(association, cross-linking study)
Byron et al., Proteomics 2012
-
IRef Intact Interaction:
Complex of MCMBP-MCM5-MCM3-MCM4-SMC3-MCM6-MCM7
(association, anti bait coimmunoprecipitation)
Nguyen et al., PloS one 2012
-
IRef Intact Interaction:
Complex of 203 proteins
(association, cross-linking study)
Byron et al., Proteomics 2012
-
IRef Intact Interaction:
Complex of 79 proteins
(association, anti bait coimmunoprecipitation)
Huang et al., Cancer Cell 2013
-
IRef Intact Interaction:
Complex of 37 proteins
(association, cosedimentation through density gradient)
Nguyen et al., PloS one 2012
-
IRef Intact Interaction:
Complex of 13 proteins
(association, cosedimentation through density gradient)
Nguyen et al., PloS one 2012
-
IRef Intact Interaction:
Complex of 11 proteins
(association, cosedimentation through density gradient)
Nguyen et al., PloS one 2012
-
IRef Intact Interaction:
Complex of MCM6-MCMBP-MCM4
(association, anti bait coimmunoprecipitation)
Sakwe et al., Mol Cell Biol 2007
-
IRef Intact Interaction:
Complex of MCM4-MCM6-MCM4-MCM7-MCMBP-MCM7-MCMBP-MCM6
(physical association, cosedimentation)
Sakwe et al., Mol Cell Biol 2007
-
IRef Intact Interaction:
Complex of MCM5-MCMBP-MCM4-MCM3-MCM6-MCM2-MCM7
(association, tandem affinity purification)
Sakwe et al., Mol Cell Biol 2007
-
IRef Ophid Interaction:
MCM4
—
MCM6
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Findeisen et al., Eur J Biochem 1999
:
High
cyclin E kinase activity
allows the binding of Xenopus ORC and Cdc6, but not
MCM , to sperm chromatin, even though the kinase does not phosphorylate MCM directly
Odom et al., Science 2000
:
The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to
Arg82 , a
regulator of the transcriptional complex
ArgR-Mcm1
Izumi et al., Nucleic Acids Res 2000
:
Mcm10 is a nuclear protein that is localized to replication origins and
mediates the interaction of the
Mcm2-7 complex with replication origins
Murphy et al., Vet Surg 2000
:
These effects were prevented in the canine explants by simultaneous treatment with MPS at 1 and 0.1 mg/mL, and
proteoglycan release
induced by
MCM in equine articular cartilage was inhibited by 1 mg/mL MPS
Measday et al., Genes Dev 2002
:
We used chromatin immunoprecipitation to demonstrate that Ctf3p, Mcm22p, and
Mcm16p bind to CEN DNA in a
Ctf19p dependent manner
Wohlschlegel et al., Mol Cell 2002
:
Current models suggest that the replication initiation factor
Mcm10 is
required for association of
Mcm2-7 with origins of replication to generate the prereplicative complex (pre-RC)
You et al., J Biol Chem 2002
:
Because uncomplexed Mcm7 displayed neither ATPase nor DNA helicase activity,
Mcm7 contributes to the DNA helicase activity of the
Mcm complex through interaction with other subunits ... Biol. 19, 8003-8015 ), our data indicate distinct
roles of Mcm4,
Mcm6 , and Mcm7 subunits in activation of the DNA helicase activity of the
Mcm4/6/7 complex
Tesfaigzi et al., J Immunol 2002
(Eosinophilia...) :
IFN-gamma caused Bax expression in
IL-13 induced
MCM in microdissected airway cultures
Fennessy et al., Circulation 2003
:
MCM taken from smokers impaired the release of nitric oxide and
increased the levels of
endothelin-1 release from HUVECs
Ishimi et al., J Biol Chem 2003
:
Based on results that showed that the DNA helicase activity of the
MCM4-6-7 complex is negatively
regulated by
CDK2 phosphorylation, we suggest that the phosphorylation of MCM4 in the checkpoint control inhibits DNA replication, which includes blockage of DNA fork progression, through inactivation of the MCM complex
Gregan et al., Mol Biol Cell 2003
:
However, unlike the situation in Xenopus, where
Mcm10 chromatin binding is
dependent on
Mcm2-7 , we show that the fission yeast protein is bound to chromatin throughout the cell cycle in growing cells, and only displaced from chromatin during quiescence
Bruemmer et al., Exp Cell Res 2003
(Coronary Restenosis...) :
In combination, these data demonstrate that the ERK/MAPK signal transduction pathway plays a central role in regulating
E2F dependent
MCM expression and DNA replication in VSMC
Savli et al., Int J Neurosci 2004
:
In the present study, the authors aimed to evaluate the
effect of
microglia conditioned medium (MCM) on
brain derived neurotrophic factor (BDNF) gene expression of astrocytes by quantitative real-time polymerase chain reaction ( PCR )
Peterson et al., Biochem Pharmacol 1992
(Liver Diseases) :
Catalase partially
blocked the AHH inhibitory activity of
MCM suggesting that activated oxygen intermediates are partially involved in the AHH inhibitory activity of the MCM
Venugopal et al., Am J Pathol 2005
:
To mimic the in vivo situation, we examined whether vascular smooth muscle cell ( VSMC ) and/or
macrophage conditioned media (MCM) could
augment CRP production by HAEC
Juang et al., Chemosphere 2006
:
It was experimentally concluded that when the
effect of interactions between large dyes ( such as BV10 ) and
MCM-41 on the pore structure stability of
MCM-41 was insignificant, MCM-41 might be a good adsorbent for the removal of basic dyes from wastewater
Kasiviswanathan et al., J Bacteriol 2006
:
Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of
MCM with Cdc6
inhibits the DNA binding activity of
Cdc6
Kawasaki et al., Genes Cells 2006
:
However,
Mcm2-7p does bind in the
presence of exogenous Cdt1p or
Cdt1p-Mcm2-7p complex
Peng et al., Glia 2006
(AIDS Dementia Complex...) :
The
MCM induced production of
SDF-1 was prevented by IL-1beta receptor antagonist (IL-1Ra) and IL-1beta siRNA treatment of human MDM. These laboratory observations were confirmed in severe combined immunodeficient ( SCID ) mice with HIV-1 encephalitis ( HIVE )
Xiang et al., Am J Respir Cell Mol Biol 2008
(Metaplasia) :
IL-9 or
IL-13 induced MCM independently, but a combined IL-9/IL-13 treatment
enhanced MCM synergistically ...
IL-9 or IL-13 induced MCM independently, but a combined IL-9/IL-13 treatment
enhanced MCM synergistically ... While
IL-9/IL-13 induced
MCM in bronchioles microdissected from bax ( +/+ ) and bax ( -/- ) mice to a similar extent, IFN-gamma treatment reduced MCM only in bronchioles from bax ( +/+ ) but not in bax ( -/- ) bronchioles ... While
IL-9/IL-13 induced
MCM in bronchioles microdissected from bax ( +/+ ) and bax ( -/- ) mice to a similar extent, IFN-gamma treatment reduced MCM only in bronchioles from bax ( +/+ ) but not in bax ( -/- ) bronchioles
Peng et al., Glia 2008
(HIV Infections) :
Conditioned media from
lipopolysaccharide (LPS) activated MDM ( LPS-MCM ) or HIV infected MCM (
HIV-MCM ) induced a profound increase in NPC proliferation
Xie et al., Proc Natl Acad Sci U S A 2008
:
We show by alpha-amanitin inhibition that
RNA polymerase II (RNAPII) transcription is
required to localize
MCM2-7 ( but not ORC ) to permit the second round of origin firing
Pawluczyk et al., Nephrol Dial Transplant 2009
(Disease Models, Animal...) :
Fibronectin and IL-1beta levels were enhanced proportionately between the sexes in
response to
MCM stimulation, whilst the increase in TNFalpha levels was greater in MCM stimulated female cells ... Fibronectin and
IL-1beta levels were enhanced proportionately between the sexes in
response to
MCM stimulation, whilst the increase in TNFalpha levels was greater in MCM stimulated female cells
Hu et al., Glia 2009
:
Bath application of
LPS stimulated
MDM conditioned media (MCM) enhanced neuronal I ( K ) in a concentration dependent manner, whereas non stimulated MCM failed to alter neuronal I ( K )
Majid et al., Cancer Res 2010
(Prostatic Neoplasms) :
Here, we examined the
role of
MCM2 in prostate cancer and the effect of microRNA-1296 (miR-1296), genistein, and trichostatin A (TSA) on the
MCM complex ... Here, we examined the role of MCM2 in prostate cancer and the
effect of
microRNA-1296 (miR-1296) , genistein, and trichostatin A (TSA) on the
MCM complex ... Here, we examined the role of MCM2 in prostate cancer and the
effect of microRNA-1296 (miR-1296), genistein, and
trichostatin A (TSA) on the
MCM complex
Kundu et al., Nucleic Acids Res 2010
:
Deregulated
Cdc6 inhibits DNA replication and
suppresses Cdc7 mediated phosphorylation of
Mcm2-7 complex ... Deregulated Cdc6 inhibits DNA replication and suppresses
Cdc7 mediated phosphorylation of
Mcm2-7 complex ... Remarkably,
Cdc6 itself does not directly inhibit Cdc7 kinase activity towards Mcm2-4-6-7 in purified systems, rather
modulates Mcm2-7 phosphorylation on chromatin context ... Remarkably, Cdc6 itself does not directly inhibit
Cdc7 kinase activity towards Mcm2-4-6-7 in purified systems, rather
modulates Mcm2-7 phosphorylation on chromatin context ... Taken together, we propose that Cdc6 on chromatin acts as a modulator of
Cdc7 mediated phosphorylation of
Mcm2-7 , and thus destabilization of Cdc6 from chromatin after licensing is a key event ensuring proper transition to the initiation of DNA replication
Han et al., Genes Dev 2010
:
Loss of
Rtt101 also
reduces binding of FACT to
MCM , but not the association of FACT with Leo1 and Spt5, two proteins involved in transcription
Mogavero et al., Antimicrob Agents Chemother 2011
:
These results demonstrate a differential
requirement for the coregulator
Mcm1 for
Cap1- and Mrr1 mediated MDR1 upregulation ... These results demonstrate a differential
requirement for the coregulator
Mcm1 for Cap1- and Mrr1 mediated
MDR1 upregulation
Stead et al., Nucleic Acids Res 2011
:
In vitro, phosphorylation of
Mcm2 or Mcm2 ( EE )
reduces the helicase activity of
Mcm2-7 while increasing DNA binding ... In vitro, phosphorylation of Mcm2 or
Mcm2 ( EE )
reduces the helicase activity of
Mcm2-7 while increasing DNA binding
Chen et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
By using specific inhibitors and small interfering RNAs, we demonstrate that the activation of the JNK and p38 MAPK pathways are critical for
HG-MCM induced
E-selectin expression ... The inhibition of NF-?B and AP-1 activation by specific siRNAs blocks the
HG-MCM induced
E-selectin promoter activity and expression
Dang et al., J Biol Chem 2011
:
Here, we demonstrated that the CMG complex is formed in vivo in trypanosomes and that
Mcm2-7 helicase activity is
activated by the association with
Cdc45 and the GINS complex in vitro ... Here, we demonstrated that the CMG complex is formed in vivo in trypanosomes and that
Mcm2-7 helicase activity is
activated by the association with Cdc45 and the
GINS complex in vitro
Bruck et al., J Biol Chem 2011
:
Sld2 interaction with
Mcm2-7 blocks the interaction between
GINS and Mcm2-7
Wu et al., J Cell Sci 2012
:
We demonstrate that disruption of the interaction between
Cdt1p and Mcm6p
prevents the formation of the
MCM complex , excludes Mcm2-7p from the nucleus, and inhibits pre-RC assembly and DNA replication ... We demonstrate that disruption of the interaction between Cdt1p and
Mcm6p prevents the formation of the
MCM complex , excludes Mcm2-7p from the nucleus, and inhibits pre-RC assembly and DNA replication
Nguyen et al., PloS one 2012
:
In vitro kinase assays showed that
MCM-BP was not a substrate for DDK but could
inhibit DDK phosphorylation of
MCM4,6,7 within MCM4,6,7 or MCM2-7 complexes, with little effect on DDK phosphorylation of MCM2
Cho et al., Proc Natl Acad Sci U S A 2013
:
The
Tim-Tipin complex, reconstituted and purified using the baculovirus expression system, interacts directly with Mcm complexes and
inhibits the single stranded DNA dependent ATPase activities of the
Mcm2-7 and Mcm4/6/7 complexes, the DNA unwinding activity of the Mcm4/6/7 complex, and the DNA unwinding and ATPase activity of Cdc45-Mcm2-7-GINS complex, the presumed replicative DNA helicase in eukaryotes ... The
effects of
Tim-Tipin on the catalytic activities of the
Mcm complexes and DNA pols are mediated by the Tim protein alone, and distinct regions of the Tim protein are responsible for the inhibition of Mcm complex activities and stimulation of DNA pols
Evrin et al., Nucleic Acids Res 2013
:
Our findings illustrate how conserved Cdc6 AAA+ motifs modulate MCM2-7 recruitment, show that
ATPase activity is
required for
MCM2-7 hexamer dimerization and demonstrate that MCM2-7 hexamers are recruited to origins in a consecutive process
Hubbi et al., Science signaling 2013
:
In response to hypoxia,
HIF-1a bound to Cdc6, a protein that is essential for loading of the minichromosome maintenance (MCM) complex ( which has DNA helicase activity ) onto DNA, and
promoted the interaction between Cdc6 and the
MCM complex ... Although the interaction between Cdc6 and the MCM complex increased the association of the MCM proteins with chromatin, the binding of HIF-1a to the complex decreased phosphorylation and
activation of the
MCM complex by the kinase
Cdc7 ... Although the interaction between Cdc6 and the
MCM complex increased the association of the MCM proteins with chromatin, the binding of
HIF-1a to the complex decreased phosphorylation and activation of the MCM complex by the kinase Cdc7
Das et al., PloS one 2013
:
Binding and function of
MCM2-7 to pre-replication complex is regulated by MCM10
mediated binding of
RECQL4 with MCM2-7
Stefanovic et al., Kidney Int 1989
:
The
effect of
MCM on
ecto-5'-nucleotidase activity was apparent after 24 hours and increased with time
Wang et al., Mol Gen Genet 1994
:
It has been previously demonstrated that
MCM1 and STE12 are transcriptional
activators of a-specific genes such as
STE6 , and we now show that SWI1 is also required for STE6 expression
Sible et al., Curr Biol 1998
:
The periodic association of the
MCM complex with chromatin may be
regulated via phosphorylation by
cyclin dependent kinases (Cdks) [ 11 ]
Behzadian et al., Glia 1998
(Anoxia) :
Adsorption of MCM by specific antibodies as well as Western and Northern blot analysis indicated that stimulating and inhibitory activities of
MCM are
due to the presence of
VEGF and TGF-beta, respectively
Culig et al., Br J Cancer 1998
(Prostatic Neoplasms) :
The
effects of
MCM on cellular proliferation, AR protein and
PSA secretion were abolished by pretreatment of MCM with a neutralizing anti-IL-1beta antibody