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TP53 — TUBB
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Naoe et al., Cancer Sci 2006
(Hematologic Neoplasms...) :
Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking,
centrosome duplication and
regulation of
p53
Bergstralh et al., Exp Cell Res 2007
(Lung Neoplasms) :
Mass spectroscopy identified the protein as nucleophosmin/B23 (NPM), a multifunctional protein with diverse roles : ribosome biosynthesis,
p53 regulation , nuclear-cytoplasmic shuttling, and
centrosome duplication
Lee et al., Proc Natl Acad Sci U S A 2009
(Cell Transformation, Neoplastic...) :
Consistent with the in vivo observations, and the demonstration of a direct interaction between p53 and ASCOM, cell based assays have revealed that
ASCOM , through ASC-2 and MLL3/4, acts as a p53 coactivator and is
required for H3K4-trimethyation and expression of endogenous
p53-target genes in response to the DNA damaging agent doxorubicin
Mantel et al., Blood 1999
(Polyploidy) :
p53 has already been implicated in
centrosome regulation