◀ Back to RELA

PTK6 — RELA

Text-mined interactions from Literome

Shames et al., J Surg Res 1999 : LPS Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent ... PTK inhibition with Gen attenuated both LPS induced NF-kappaB DNA binding and TNF-alpha production in human monocytes ... Furthermore, our results provide evidence that PTK plays a role in LPS induced NF-kappaB activation and TNF-alpha release in human monocytes and thus could be a potential therapeutic target in inflammatory states
Kang et al., J Toxicol Environ Health 2000 : Specific inhibitors of protein tyrosine kinase , such as herbimycin A, genistein, and AG-494, prevented NF-kappaB activation in silica treated cells
Kang et al., Toxicology 2000 : A specific inhibitor of protein tyrosine kinase ( PTK ) , genistein, prevented the NF-kappaB activation induced by pervanadate in the presence of silica while inhibitors of protein kinase A or C, such as staurosporine or H7, had no inhibitory effect on NF-kappaB activation
Kokura et al., J Vasc Res 2001 : However, both A/R- and redox induced NF kappa B activation was blocked by inhibition of PTK
Kang et al., Mol Cell Biochem 2000 : Specific inhibitors of protein tyrosine kinase , such as genistein and AG494, prevented NF-kappaB activation in SNP- or SIN-1 treated cells, suggesting involvement of tyrosine kinase in the NO signaling pathway leading to NF-kappaB activation
Roebuck et al., J Bone Miner Res 2001 (Osteosarcoma) : Protein tyrosine kinase ( PTK ) inhibitors, which significantly reduce the suppressive effect of titanium particles on collagen gene expression, inhibited NF-kappaB binding activity showing that titanium particle stimulation of PTK signals in osteoblasts are critical for both NF-kappaB activation and collagen gene expression
Waris et al., Biochem Pharmacol 2002 (Hepatitis C) : The inhibitory effect of protein tyrosine kinase ( PTK ) inhibitors indicates the involvement of PTK in NF-kappaB activation by NS5A
Takada et al., J Biol Chem 2003 : We present several lines of evidence to suggest that the Syk protein-tyrosine kinase is involved in H2O2 induced NF-kappaB activation
Iwasaki et al., FEBS Lett 1992 : Since a number of growth factors signal via protein tyrosine kinase, in this study we examined a possible involvement of protein tyrosine kinase in the IL-1 alpha induced NF-kappa B
Sumi et al., Yakugaku Zasshi 2007 : Although IKKbeta activates transcription factor NF-kappaB and PTP1B negatively regulates the receptor-protein tyrosine kinase , such as epidermal growth factor receptor (EGFR) in cells, covalent modification of these proteins caused by 1,2-NQ results in inhibition of NF-kappaB activity and transactivation of EGFR
MacLeod et al., Clinical and vaccine immunology : CVI 2008 : PorB induced NF-kappaB nuclear translocation was not dependent on either PTK or Erk1/2 activities
Geng et al., J Immunol 1993 : Both PTK inhibitors also reduced the LPS activation of nuclear factor-kappa B (NF-kappa B) , which is a transcription factor involved in the expression of cytokine genes such as IL-6 and TNF-alpha ... In summary, these findings suggest that protein kinase C and protein kinase A appear to have selective effects in the LPS induction of cytokines, whereas PTK is required for LPS induction of a broad spectrum of cytokines and NF-kappa B activation in monocytes
Trede et al., J Immunol 1993 (Leukemia, Monocytic, Acute) : Induction of both NF-kappa B DNA binding proteins and NF-kappa B enhancer function was down-regulated by inhibitors of protein kinase C and protein tyrosine kinase , indicating a role for these protein kinases in the induction of NF-kappa B by MHC class II ligands
Umansky et al., Int Immunol 1996 (Newcastle Disease) : NDV mediated NO synthesis and NF-kappa B activation were blocked by an antioxidant ( butylated hydroxyanisole ), by an inhibitor of protein tyrosine kinase ( genistein ) and of protein kinase A ( H-89 ), but not by an inhibitor of protein kinase C ( staurosporin )
Zhu et al., Biochim Biophys Acta 1997 : The increases of ICAM-1 mRNA and NF-kappa B binding were inhibited by the protein tyrosine kinase inhibitors, genistein and lavendustin A, but not by inhibitors for cyclic AMP dependent protein kinases or protein kinase C
Sodhi et al., Immunol Lett 1998 : It was observed that cisplatin induced NF-kappaB translocation involves serine/threonine phosphatases 1/2A, protein tyrosine phosphatases and genestein sensitive protein tyrosine kinase activities
Lazaar et al., J Immunol 1998 : These results delineate a potentially important CD40 mediated signal-transduction pathway in ASM, involving protein tyrosine kinase dependent calcium mobilization, NF-kappaB activation, and IL-6 production