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FOXP3 — IL21
Text-mined interactions from Literome
Fantini et al., Eur J Immunol 2007
(Colitis...) :
Here we demonstrate that
IL-21 , a type-1 cytokine produced by T cells and involved in the pathogenesis of immune mediated diseases,
prevents the TGF-beta dependent expression of
FoxP3 , the master regulator of T ( reg ) cell commitment, and the induction of suppressive capacity in naive CD4 ( + ) T cells, while promoting the differentiation of Th17 cells
Li et al., Blood 2008
:
IL-21 mediated
Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes
Xiao et al., J Immunol 2008
(Autoimmune Diseases) :
Herein we show that RA enhances TGF-beta signaling by increasing the expression and phosphorylation of Smad3, and this results in increased
Foxp3 expression even in the
presence of IL-6 or
IL-21
Chaput et al., Gut 2009
(Adenocarcinoma...) :
Finally,
interleukin 6 and TGF beta 1 synergistically
induced the generation of CD8 ( + ) CD25 ( + )
Foxp3 ( + ) T cells ex vivo
Hiramatsu et al., J Leukoc Biol 2010
:
Finally, we found that
Foxp3 bound to IL-21P and the CNS-2 enhancer and
inhibited c-Maf induced
IL-21 production modestly but significantly in CD4 ( + ) T cells
Niu et al., Hum Immunol 2010
(Arthritis, Rheumatoid) :
IL-21 potently enhances Th17 proliferation and
suppresses Foxp3 expression, leading to the expression of RORC