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DEFB103B — IL13

Text-mined interactions from Literome

Nomura et al., J Immunol 2003 (Dermatitis, Atopic...) : Because HBD-2, IL-8, and iNOS are known to be inhibited by Th2 cytokines, we examined the effects of IL-4 and IL-13 on HBD-3 expression in keratinocyte culture in vitro ... We found that IL-13 and IL-4 inhibited TNF-alpha- and IFN-gamma induced HBD-3 production
Howell et al., Clin Immunol 2006 (Dermatitis, Atopic...) : Furthermore, we demonstrate the down-regulatory effect of IL-4, IL-10, and IL-13 - which are over expressed in the skin of AD patients - on HBD-3 expression in keratinocytes
Howell et al., J Invest Dermatol 2008 (Acute Disease...) : Importantly, transduction of p21-recombinant protein into keratinocytes prevented IL-4/IL-13 mediated inhibition of FLG and HBD-3 expression