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E2F1 — GSK3B
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yeste-Velasco et al., Neuropharmacology 2007
(Potassium Deficiency) :
Primary cerebellar granule cells ( CGNs ) were used in this study to determine whether pharmacological inhibition of
GSK-3beta is
involved in neuronal modulation of the cell cycle, and specifically in the regulation of
E2F-1 and retinoblastoma protein ( Rb ) ... Our data indicate that
GSK-3beta inhibition
regulates , in part, the cell cycle in CGNs by inhibiting Rb phosphorylation and thus inhibiting
E2F-1 activity
Zhou et al., J Biol Chem 2008
:
Both wild-type
GSK3beta and its kinase-defective mutant GSK3beta KM can
inhibit E2F1 by promoting its ubiquitination through physical interaction