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EGFR — TNS3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of EGFR-TNS3 → EGF (increases) Cui et al., Mol Cancer Res 2004*
  Evidence: Addition of EGF to the cells induces dephosphorylation of these two molecules, leads to disassociation of the tensin3-focal adhesion kinase-p130Cas complex, and enhances the interaction between tensin3 and EGF receptor.
• OpenBEL Selventa BEL large corpus: TNS3 → EGFR (increases, TNS3 Activity)
  Evidence: This is taken from supplemental table 2 from PMID 15951569 Cut-offs were 2.25 for increase and 0.5 for decrease LLID were found by converting from GI assession numbers in DAVID Spreadsheet is saved in the project folder for Cell Signaling Project # bduckworth
• OpenBEL Selventa BEL large corpus: TNS3 → EGFR (increases, TNS3 Activity) Cui et al., Mol Cancer Res 2004*
  Evidence: EGF induces tyrosine phosphorylation of tensin3 in MDA-MB-468 cells in a time- and dose-dependent manner
• OpenBEL Selventa BEL large corpus: TNS3 → EGFR (increases, TNS3 Activity) Cui et al., Mol Cancer Res 2004*
  Evidence: EGF induces tyrosine phosphorylation of tensin3 in MDA-MB-468 cells in a time- and dose-dependent manner, but it is independent of an intact actin cytoskeleton or phosphatidylinositol 3-kinase.